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| | 6-Chloro-1-tetralone Basic information |
| Product Name: | 6-Chloro-1-tetralone | | Synonyms: | 6-CHLORO-TETRAL-1-ON;6-Chloro-1-tetralone;6-Chloro-α-Tetralone;5-CHLORO-L-INDOMONE;6-Chloro-tetral-1-one;6-Chloro-3,4-dihydro-2H-naphthalen-1-one;6-Chloro-1-tetralone 98%;6-chlorotetralin-1-one | | CAS: | 26673-31-4 | | MF: | C10H9ClO | | MW: | 180.63 | | EINECS: | 808-038-7 | | Product Categories: | 11 | | Mol File: | 26673-31-4.mol |  |
| | 6-Chloro-1-tetralone Chemical Properties |
| Melting point | 53 °C | | Boiling point | 150°C/0.7mmHg(lit.) | | density | 1.248±0.06 g/cm3(Predicted) | | refractive index | 1.59 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to lump | | color | White to Yellow to Orange | | CAS DataBase Reference | 26673-31-4 |
| | 6-Chloro-1-tetralone Usage And Synthesis |
| Uses | 6-Chloro-1-tetralone is a novel and potent intermediate used for synthesis of pharmaceutical compounds. | | Synthesis | A solution of sodium nitrite (173 mg, 2.51 mmol) in water (5 mL) at 0 °C (ice-bath) was added to a
magnetically stirred suspension of 6-Amino-1-tetralone (360 mg, 2.23 mmol) in aqueous hydrochloric acid (10 mL, 6
M) at 0 °C. This reaction mixture was added dropwise to a solution of copper(I) chloride (267 mg,
2.70 mmol) in concentrated hydrochloric acid (5 mL) at 0 °C. It was allowed to warm up to room
100 temperature and stirred for a further 2 h after which it was neutralised with solid sodium carbonate,
extracted with ethyl acetate (3 × 20 mL) and concentrated in vacuo to give slightly yellow oil. This
material was subjected to flash chromatography (50% chloroform in hexane) and concentration of
the appropriate fractions afforded 6-chloro-1-tetralone (180 mg, 45%) as a waxy solid. |
| | 6-Chloro-1-tetralone Preparation Products And Raw materials |
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