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| | BERBERINE CHLORIDE Basic information |
| Product Name: | BERBERINE CHLORIDE | | Synonyms: | Berberine (berberine hydrochloride);Berberine chloride hydrate 97%;9,10-DiMethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-iuM chloride hydrate;Berberine chloride hydrate technical, >=90% (AT);Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride, hydrate (1:1:);LABOTEST-BB LT00440956;CI 75160;BERBERIN HCL | | CAS: | 141433-60-5 | | MF: | C20H20ClNO5 | | MW: | 389.83 | | EINECS: | 211-195-9 | | Product Categories: | Alkaloids;Biochemistry;Miscellaneous Natural Products;Isoquinoline Alkaloids | | Mol File: | 141433-60-5.mol |  |
| | BERBERINE CHLORIDE Chemical Properties |
| Melting point | 204-206 °C (dec.) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | Colour Index | 75160 | | form | Solid | | color | Pale Yellow to Yellow | | Water Solubility | Soluble in water. | | Sensitive | Light Sensitive | | Merck | 14,1154 | | BRN | 3836585 | | Stability: | Hygroscopic | | InChIKey | VKJGBAJNNALVAV-UHFFFAOYSA-M | | CAS DataBase Reference | 141433-60-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | WGK Germany | 2 | | RTECS | DR9866400 | | F | 3-10 | | TSCA | Yes | | HS Code | 29399990 |
| | BERBERINE CHLORIDE Usage And Synthesis |
| Description | This alkaloid occurs together with Neprotine (q.v.) in Berberis insignis Hook, B.
umbellata Wall and Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng.).
It is optically inactive and crystallizes from H2O with 5.5 H2O. It yields crystal_x0002_line salts, e.g. the nitrate, m.p. 265-7°C (dec.); sulphate, m.p. 271-3°C (dec.)
and the picrate, m.p. 231°C (dec.). The base also furnishes a methyl ether, m.p.
265°C and on catalytic hydrogenation gives the tetrahydro derivative, m.p.
213-5°C (dec.). The ultraviolet spectrum resembles that of berberine (q.v.).
Oxidation with KMn04 in Me2CO gives hemipinic acid, identified as the
ethylimide, m.p. 90°C. | | Uses | Primarily for the treatment of gastroenteritis, dysentery and other intestinal infections and conjunctivitis, purulent otitis media. | | References | Orekhov.,J. Amer. Pharm. Assoc., 30,247, (1941)
Chatterjee., ibid, 33,205,210 (1944) |
| | BERBERINE CHLORIDE Preparation Products And Raw materials |
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