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| | Kinetin Basic information |
| | Kinetin Chemical Properties |
| Melting point | 269-271 °C (dec.)(lit.) | | Boiling point | 355.49°C (rough estimate) | | density | 1.2639 (rough estimate) | | refractive index | 1.7610 (estimate) | | Fp | 269-271°C | | storage temp. | -70°C | | solubility | H2O: soluble | | form | crystalline | | pka | pKa1 2.7; pKa2 9.9(at 25℃) | | color | white | | Water Solubility | Soluble in water (<1 mg/ml) at 25°C, Acetic acid (49.00-51.00 mg/ml), DMSO (43 mg/ml) at 25°C, ethanol (<1 mg/ml) at 25°C, 0.1 N Sodium hydroxide (1% w/v), methanol (slightly), and dilute aqueous hydrochloric acid or sodium hydroxide (freely). | | Decomposition | 269-271 ºC | | Merck | 14,5311 | | BRN | 21703 | | InChIKey | QANMHLXAZMSUEX-UHFFFAOYSA-N | | LogP | 1.200 (est) | | CAS DataBase Reference | 525-79-1(CAS DataBase Reference) | | NIST Chemistry Reference | Kinetin(525-79-1) | | EPA Substance Registry System | Kinetin (525-79-1) |
| | Kinetin Usage And Synthesis |
| Description | Kinetin (or Vivakin) was introduced as Kinerase in the US as a new
ingredient for the treatment of age related photodamage of skin. This 6-
furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and
was shown to be a highly potent growth factor. In vitro, it was able to delay or
prevent the onset of age-related changes in skin cells without affecting cellular
lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the
clinical signs of photodamaged skin and demonstrated a good safety profile.
It could have potential in psoriasis as well as in other proliferative skin disorders. | | Description | Kinetin is a cytokinin plant growth regulator with diverse biological activities. Kinetin (0.23 μM) increases p34cdc2-like histone H1 kinase activity, the number of cells in mitosis, and total cell number in arrested N. plumbaginifolia cells. It increases GSH levels and activity of glutathione peroxidase and glutathione reductase, but reduces thiobarbituric acid reactive substances (TBARS) levels, in human skin fibroblasts when used at a concentration of 10 μM. Kinetin (40 μM) reduces age-related enlargement, multinucleation, and accumulation of cellular debris in human mammary skin fibroblasts without affecting proliferative lifespan. | | Chemical Properties | White Solid | | Originator | Senetek (UK) | | Uses | Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures. | | Uses | Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst). | | Uses | A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures | | Definition | ChEBI: Kinetin is a member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. It has a role as a geroprotector and a cytokinin. It is a member of furans and a member of 6-aminopurines. | | Brand name | Kinerase | | Synthesis Reference(s) | The Journal of Organic Chemistry, 21, p. 1276, 1956 DOI: 10.1021/jo01117a016 | | General Description | Kinetin is an artificial?cytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division. | | Biochem/physiol Actions | FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity. | | Purification Methods | It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.] |
| | Kinetin Preparation Products And Raw materials |
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