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| | ALFAXALONE Basic information |
| Product Name: | ALFAXALONE | | Synonyms: | 3ALPHA-HYDROXY-5ALPHA-PREGNANE-11,20-DIONE;3-HYDROXY-5ALPHA-PREGNANE-11,20-DIONE;5ALPHA-PREGNAN-3ALPHA-OL-11,20-DIONE;ALFAXALONE;ALPHAXALONE;(3-alpha,5-alpha)-3-hydroxypregnane-11,20-dione;20-dione,3-alpha-hydroxy-5-alpha-pregnane-1;20-dione,3-hydroxy-,(3-alpha,5-alpha)-pregnane-1 | | CAS: | 23930-19-0 | | MF: | C21H32O3 | | MW: | 332.48 | | EINECS: | | | Product Categories: | | | Mol File: | 23930-19-0.mol |  |
| | ALFAXALONE Chemical Properties |
| Melting point | 172-174° | | alpha | D26 +113.4° (c = 1.2 in chloroform). | | Boiling point | 409.59°C (rough estimate) | | density | 1.0834 (rough estimate) | | refractive index | 1.5192 (estimate) | | storage temp. | Store at RT | | solubility | chloroform: ≥5 mg/mL, clear, colorless | | pka | 15.05±0.70(Predicted) | | form | powder | | color | white |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 22-36 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | TU4157800 | | Toxicity | LD50 i.v. in mice: 43 mg/kg (Al-Khawashki) |
| | ALFAXALONE Usage And Synthesis |
| Originator | Althesin ,Glaxo ,UK ,1972 | | Uses | Anesthetic;nociception blocker | | Definition | ChEBI: Alphaxolone is a corticosteroid hormone. | | Manufacturing Process | A solution of 3α-hydroxy-5α-pregn-16-ene-11,20-dione (200 mg) in freshly
distilled tetrahydrofuran (8 ml) with 5% palladium on carbon (100 ml) was
hydrogenated until hydrogen uptake ceased. The mixture was filtered through
a pad of kieselguhr and the tetrahydrofuran removed in vacuum to give 196
mg, MP 171°C to 172°C. | | Therapeutic Function | Anesthetic component | | Biological Activity | A neurosteroid anesthetic that directly activates and potentiates GABA A receptor-activated membrane current (I GABA ). Efficacy but not potency is determined by the alpha subunit of the receptor (EC 50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μ M for α 1 β 1 γ 3, α 1 β 1 γ 1, β 1 γ 1, α 2 β 1 γ 2L and α 1 β 1 γ 2L isoforms respectively). |
| | ALFAXALONE Preparation Products And Raw materials |
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