ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Nitropyridine 3-Nitropyridine

3-Nitropyridine

3-Nitropyridine Basic information
Product Name:3-Nitropyridine
Synonyms:Pyridine, 3-nitro-;3-NITROPYRIDINE;5-Nitropyridine;3-Nitropyridine,98%;3-Nitropyridine>;3-NITROPYRIDINE ISO 9001：2015 REACH;SKL066;Nicotinic EP Impurity H
CAS:2530-26-9
MF:C5H4N2O2
MW:124.1
EINECS:
Product Categories:Aromatics;Heterocycles;Pyridine
Mol File:2530-26-9.mol
3-Nitropyridine Structure
3-Nitropyridine Chemical Properties
Melting point 35-40 °C
Boiling point 216°C
density 1,33 g/cm3
refractive index 1.4800 (estimate)
Fp 216°C
storage temp. Flammables area
solubility soluble in Methanol
form Liquid
pkapK1:0.79(+1) (25°C,μ=0.02)
color Clear colorless
BRN 111969
CAS DataBase Reference2530-26-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn-F,Xn,F
Risk Statements 20/21/22-11-41-37/38-22
Safety Statements 37/39-26-16-39
RIDADR 2811
WGK Germany 3
HazardClass 6.1
PackingGroup III
HS Code 29333999
MSDS Information
ProviderLanguage
ACROS English
ALFA English
3-Nitropyridine Usage And Synthesis
Chemical Propertieswhite to yellow needle-like crystals
Uses3-Nitropyridine is used in the novel synthesis of biologically active nitro heterocyclic compounds.
SynthesisIn 1993 Suzuki and co-workers reported the nitration of pyridine with nitrogen dioxide and ozone in dichloromethane at room temperature. They obtained a 3.5 % yield of 3-nitropyridine and 1.2 % of 3,5-dinitropyridine.
3-Nitropyridine synthesis from nitration of pyridine
3-Nitropyridines can also be synthesized by oxidation of 3-aminopyridine with hydrogen peroxide in fuming sulphuric acid in 45% yield. Nitration of 2,6-dichloropyridine with nitronium tetrafluoroborate gave a 11% yield of 3-nitropyridine after dehalogenation. 3-nitropyridine has also been prepared from 2- chloro-3-nitropyridine.
3-Nitropyridine Preparation Products And Raw materials
Preparation Products6-Azaindole-->2-Acetamido-5-nitropyridine-->2-Amino-5-nitropyridine-->Isopropyl-(5-nitro-pyridin-2-yl)-aMine-->(4-bromo-phenyl)-(5-nitro-[2]pyridyl)-amine
4-(5-Nitropyridin-2-yl)morpholine 2-Amino-5-nitro-4-picoline 2-HYDROXY-3-NITROPYRIDINE 2-(2-AMINOETHYLAMINO)-5-NITROPYRIDINE 2-Amino-3-nitropyridine 2-HYDROXY-4-METHYL-5-NITROPYRIDINE 2-HYDROXY-4-METHYL-3-NITROPYRIDINE 2-Amino-5-nitropyridine 2-CHLORO-3-NITROPYRIDINE 2-Bromo-5-nitropyridine 2-Amino-3-nitro-4-picoline 2-CHLORO-3,5-DINITROPYRIDINE 2,2'-DITHIOBIS(5-NITROPYRIDINE) 2-Chloro-4-methyl-5-nitropyridine 2-HYDROXY-5-NITROPYRIDINE 2-Chloro-5-nitropyridine 2-Chloro-4-methyl-3-nitropyridine 5-NITRO-2-BENZYLAMINO PYRIDINE
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