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| | Fluorescein Sodium Basic information |
| | Fluorescein Sodium Chemical Properties |
| Melting point | 320 °C | | density | 0.579[at 20℃] | | vapor pressure | 2.133hPa | | storage temp. | Store at +5°C to +30°C. | | solubility | H2O: soluble1mg/mL | | Colour Index | 45350 | | form | Powder | | pka | 2.2, 4.4, 6.7(at 25℃) | | color | Rust-orange | | Odor | Odorless | | PH | 8.3 (10g/l, H2O, 20℃) | | PH Range | Pink uorescence (4.0) to green uorescence (6.0) | | Water Solubility | 500 g/L (20 ºC) | | λmax | 491nm, 493.5nm, 490nm | | Merck | 14,4159 | | BRN | 3833041 | | Stability: | Stable. | | Major Application | Nanolithography, nanoparticles, thin films, fuel cells, inks, laser, colored bubbles, cleansing products, identifying leaks in coolant, suntanning agent, hair dyes, cosmetics, dermatology, dental material, diagnosis of diabetic retinopathy, antitumor agent | | InChIKey | NJDNXYGOVLYJHP-UHFFFAOYSA-L | | LogP | 0.34 | | CAS DataBase Reference | 518-47-8(CAS DataBase Reference) | | EPA Substance Registry System | Fluorescein, disodium salt (518-47-8) |
| | Fluorescein Sodium Usage And Synthesis |
| Chemical Properties | Orange-red powder; odorless. Hygroscopic,
soluble in water; sparingly soluble in
alcohol. | | Uses | In examining subterranean waters. Serves to ascertain source of springs, connections between streams and sea, determining approx vol of water delivered by a spring, detecting source of contamination of drinking water, infiltration of soil with waste waters of factories. In externally applied drugs and cosmetics. Analytical reagent (protein label). Clinical reagent (immuno-histological stain, immuno-fluorescent label). | | Uses | Fluorescein sodium salt is a sodium salt of fluorescein. It can also be used in technical or engineered material use in-situ photochemical fabrication of transition metal-?promoted amorphous molybdenum sulfide catalysts for enhanced photosensitized hydrogen evolution. Dyes and metabolites, Environmental Testing | | General Description |
Fluorescein sodium is an orange-red to dark red powder. Water-soluble form of fluorescein. Odorless and almost tasteless. pH (5% solution) 7.8. May be sensitive to prolonged exposure to light and to heat.
| | Air & Water Reactions | Hygroscopic. Water soluble. | | Reactivity Profile | Fluorescein disodium salt is incompatible with strong oxidizers. Also incompatible with acids, acid salts and salts of heavy metals . | | Fire Hazard | Flash point data for Fluorescein disodium salt are not available; however, Fluorescein disodium salt is probably combustible. | | Safety Profile | Moderately toxic by
intraperitoneal route. Mildly toxic by
ingestion. Human systemic effects by
intravenous route: arrhythmias, eye
hemorrhage, nausea or vomiting.
Experimental reproductive effects.
Questionable carcinogen with experimental
tumorigenic data. Mutation data reported.
When heated to decomposition it emits
toxic fumes of Na2O. | | Veterinary Drugs and Treatments | Fluorescein sodium is a yellow water-soluble dye that fluoresces
under a Wood’s Lamp, but is plainly visible after binding to corneal
stroma through an ophthalmic examination light source. It is
used most commonly to delineate full thickness loss of corneal epithelium
indicating the presence of a corneal ulceration. In this instance
it will stain the corneal stroma. The epithelium is not stained
because its outer lipid cell membrane repels the stain. Descemet’s
membrane will not stain with fluorescein stain and this is used to
indicate descemetocele formation, an ocular emergency.
Fluorescein stain is applied to the precorneal tear film in dogs
and cats and the break-up of this stain with time, as observed
through a slit lamp biomicroscope using a cobalt blue light source,
is used to determine the tear film break-up time (normal 19 seconds),
an indicator of tear film quality.
Fluorescein stain is applied to the tear film of dogs to determine
patency of the nasolacrimal outflow system. The normal wait time
is 2 – 5 minutes in dogs and up to 10 minutes in cats. A positive test
indicates patency of the system. A negative test is not indicative of
disease as the test is negative in a large percentage of normal animals.
Fluorescein stain, then, can be added to irrigating solution to
flush the nasolacrimal system, making detecting the irrigation solution
at the nose more obvious during flushing of the system. | | Properties and Applications | brilliant yellow. Soluble in water and ethanol (with strong green fluorescent), water-soluble good. In strong sulfuric acid with weak for fluorescence yellow, it will be diluted with yellow precipitation. Its water solution and sodium hydroxide with dark green fluorescence for brunet solution. Mainly used for sea of target that fluorescent, facilitate aerial reconnaissance search. And can use significantly for the exploration of fluorescent groundwater. Can also be used for medicine and cosmetics shading, rarely used for silk printing and dyeing things. |
| | Fluorescein Sodium Preparation Products And Raw materials |
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