ChemicalBook Product Catalog Organic Chemistry Phosphines Tetraisopropyl methylenediphosphonate

Tetraisopropyl methylenediphosphonate

Tetraisopropyl methylenediphosphonate Basic information
Product Name:Tetraisopropyl methylenediphosphonate
Synonyms:Tetraisopropyl methylenediphosphonate,98%;Tetraisopropyl methylenediphosphonatedisc 6/01;Tetraisopropyl Methylenediphosphonate(for DisodiuM clodronate);Tetraisopropyl methylenediphosphonate 97%;Bis(propan-2-yl) {[bis(propan-2-yloxy)-phosphoryl]methyl}phosphonate;METHYLENEDIPHOSPHONIC ACID TETRAISOPROPYL ESTER;TETRAISOPROPYL(METHYLENE)BISPHOSPHONATE;TETRAISOPROPYL METHYLENEDIPHOSPHONATE
CAS:1660-95-3
MF:C13H30O6P2
MW:344.32
EINECS:216-765-0
Product Categories:Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds
Mol File:1660-95-3.mol
Tetraisopropyl methylenediphosphonate Structure
Tetraisopropyl methylenediphosphonate Chemical Properties
Boiling point 155 °C/0.5 mmHg (lit.)
density 1.08 g/mL at 25 °C (lit.)
vapor pressure 0.017Pa at 20℃
refractive index n20/D 1.431(lit.)
Fp 320 °F
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form neat
Specific Gravity1.080
color Clear Colourless to Yellow
Water Solubility Insoluble in water.
BRN 1080180
InChIKeyFKHXXJRKGVDPQP-UHFFFAOYSA-N
LogP1.3 at 20℃
CAS DataBase Reference1660-95-3(CAS DataBase Reference)
NIST Chemistry ReferenceTetraisopropyl methylenediphosphonate(1660-95-3)
EPA Substance Registry SystemPhosphonic acid, methylenebis-, tetrakis(1-methylethyl) ester (1660-95-3)
Safety Information
Hazard Codes Xi
Risk Statements 41
Safety Statements 26-36-39
WGK Germany 3
TSCA Yes
HS Code 29319090
MSDS Information
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Tetraisopropyl methylenediphosphonate English
SigmaAldrich English
ACROS English
ALFA English
Tetraisopropyl methylenediphosphonate Usage And Synthesis
Chemical PropertiesClear colorless to slightly yellow liquid
UsesTetraisopropyl methylenediphosphonate [T(iPr)MDP] forms a synergistic mixture with hydrogen dicarbollylcobaltate in nitrobenzene which was used in the extraction of europium and americium.
It may be used in the synthesis of the following:
  • tetraisopropyl ethenylidenebisphosphonate.
  • tetraisopropyl 4-acetylthiobutane-1,1-diphosphonate
  • tetraisopropyl 2-(3,5-bis(bromomethyl)phenyl)ethane-1,1-diphosphonate
UsesTetraisopropyl Methylenediphosphonate is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents. Also used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase.
General DescriptionTetraisopropyl methylenediphosphonate (IPCP) is a tetraisopropyl ester of methylenediphosphonic acid. It is an electroneutral ligand, reported to be synthesized from triisopropyl phosphate. Powder electron paramagnetic resonance (EPR) studies of tris complexes of Cu(II) complexes with IPCP has been analyzed.
TETRAMETHYL METHYLENEDIPHOSPHONATE methanedisulphonyl dichloride Methylene dithiocyanate METHYLENEDIPHOSPHONIC ACID Methanedisulphonic acid TETRAISOPROPYL VINYLIDENE DIPHOSPHONATE TETRAISOPROPYL DICHLOROMETHYLENE DIPHOSPHONATE Tetraisopropyl methylenediphosphonate Cyclopropyl methyl ketone 3-Methyl-2-butanone Titanium tetraisopropanolate BIS[(4-CHLOROPHENYL)THIOMETHYLENE]BIPHOSPHONIC ACID, TETRAISOPROPYL ESTER ALLYL METHYL ETHER TETRAISOPROPYL METHYLENEDIPHOSPHONATE, 9 7% Triisopropyl phosphite N,N-Dimethylallylamine 2-METHYLPENTANE Isopropyl myristate
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