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| | Mangostin Basic information |
| Product Name: | Mangostin | | Synonyms: | α-Mangostin, 98%, from Garcinia mangostana;α-Mangostin (a-Mangostin、ALPHA-Mangostin);α-Mangostin, froM Garcinia Mangostana;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on;Alpha-Mangostin
α-Mangostin;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one;1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE;Mangosteen | | CAS: | 6147-11-1 | | MF: | C24H26O6 | | MW: | 410.46 | | EINECS: | 683-120-1 | | Product Categories: | reagent;standard substance;Xanthones;Intermediates & Fine Chemicals;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical | | Mol File: | 6147-11-1.mol |  |
| | Mangostin Chemical Properties |
| Melting point | 180-182°C | | Boiling point | 640.1±55.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | methanol: soluble1mg/mL, clear, very light yellow | | pka | 7.22±0.20(Predicted) | | form | powder | | color | faint yellow to yellow | | λmax | 346nm(MeOH)(lit.) | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChIKey | GNRIZKKCNOBBMO-UHFFFAOYSA-N | | CAS DataBase Reference | 6147-11-1(CAS DataBase Reference) |
| | Mangostin Usage And Synthesis |
| Description | α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-β production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5 | | Chemical Properties | Yellow Crystalline Solid | | Uses | It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent | | Uses | antifungal, antilarval | | Uses | α-Mangostin has been used:
- to study its protective effect against oxidative stress mediated-retinal cell death
- to study its role as an antigenotoxic agent in DNA protection against oxidative damage
- to understand its anti-bacterial activity against Staphylococcus epidermidis?RP62A
| | Definition | ChEBI: Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether. | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Biochem/physiol Actions | Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis. | | storage | Store at -20°C | | References | 1) Mohan et al. (2018), An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach; Food Funct., 9 3860
2) Zhang et al. (2018), Identification of α-Mangostin as an Agonist of Human STING; Chem. Med. Chem.,?13 2057
3) Lee et al. (2018), Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-induced Damage; J. Mol. Sci., 19 E1484
4) Chen et al. (2017), Alpha-Mangostin Suppresses the Metastasis of Human renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity; Cell Physiol. Biochem., 44 1460
5) Xia and Sun (2018), Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment; Clin. Exp. Dermatol., 43 149 |
| | Mangostin Preparation Products And Raw materials |
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