3-Chloropivaloyl chloride

3-Chloropivaloyl chloride Basic information
Product Name:3-Chloropivaloyl chloride
Synonyms:3-CHLOROPIVALOYL CHLORIDE;3-chloro-2,2-dimethylpropaneyl chloride;3-Chloro-2,2-dimethylpropionyl chloride, tech;Propanoyl chloride, 3-chloro-2,2-dimethyl-;B-Chloropivaloyl chloride;3-CHLOROPIVALOYL CHLORIDE 98%;β-Chloropivaloyl chloride, 3-Chloropivaloyl chloride;3-chloropivaloyl chloride,3-chloro-2,2-dimethyl propinyl chloride
CAS:4300-97-4
MF:C5H8Cl2O
MW:155.02
EINECS:224-311-8
Product Categories:Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:4300-97-4.mol
3-Chloropivaloyl chloride Structure
3-Chloropivaloyl chloride Chemical Properties
Boiling point 85-86 °C60 mm Hg(lit.)
density 1.199 g/mL at 25 °C(lit.)
refractive index n20/D 1.453(lit.)
Fp 145 °F
form liquid
color Clear, colourless
Specific Gravity1.199
Water Solubility reacts
CAS DataBase Reference4300-97-4(CAS DataBase Reference)
EPA Substance Registry System3-Chloropivaloyl chloride (4300-97-4)
Safety Information
Hazard Codes C,Xi,T+
Risk Statements 34-36/37-23-22-26
Safety Statements 26-36/37/39-45-28
RIDADR UN 3390 6.1/PG 1
WGK Germany 3
19
Hazard Note Irritant
HazardClass 8
PackingGroup III
HS Code 29159000
MSDS Information
ProviderLanguage
3-Chloro-2,2-dimethylpropanoyl chloride English
SigmaAldrich English
ACROS English
3-Chloropivaloyl chloride Usage And Synthesis
Chemical Propertiesclear colorless to light yellow-brown liquid
Uses3-Chloropivaloyl Chloride is useful in the synthesis of compounds with antimicrobial and antioxidant activities.
General DescriptionA colorless liquid. Very toxic by ingestion, inhalation and skin absorption. Flash point near 70°F. Corrosive. Contact may severely irritate skin, eyes, and mucous membranes. Used to make other chemicals.
Air & Water ReactionsHighly flammable. Slightly soluble in water and less dense than water. Hence floats on water. Reacts with water to form hydrochloric acid (hydrogen chloride).
Reactivity Profile3-Chloropivaloyl chloride is incompatible with strong oxidizing agents, alcohols, bases, including amines. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health HazardTOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardCombustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
DIMETHYLMALONYL CHLORIDE 3-Chloropivaloyl chloride 1-CHLORO-2,2-DIMETHYLPROPANE 5-Bromovaleryl chloride 2-(2-Chloroethoxy)ethanol Propionyl chloride 3-Chloropropionic acid Cyclopropanecarbonyl chloride, 2,2-dichloro-1-methyl- (9CI) 2,2-Dimethyl-1,3-dichloropropane Chlorocyclohexane DIETHYLMALONIC ACID DICHLORIDE Pivaloyl chloride 1-Chloropropane N-Chlorosuccinimide Thionyl chloride 5-Chlorovaleryl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile Valeryl chloride

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