ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Chloropyridine 2-Amino-5-chloropyridine

2-Amino-5-chloropyridine

2-Amino-5-chloropyridine Basic information
Product Name:2-Amino-5-chloropyridine
Synonyms:2-Amino-5-chloropyridine ;5-Chloro-2-pyridineamine;5-Chloro-a-aminopyridine;2-Amino-5-chloropyridine ,98%;2-Amino-5-chloropyridine;2-AMINO-5-CHLOROPYRIDINE 5-CHLORO-PYRIDIN-2-YLAMINE;2-Amino-5-chlorophridine;2-AMINO-5-CHLOROPYRIDINE FOR SYNTHESIS
CAS:1072-98-6
MF:C5H5ClN2
MW:128.56
EINECS:214-020-4
Product Categories:FINE Chemical & INTERMEDIATES;Amines;PYRIDINE;Nitrogen cyclic compounds;blocks;Heterocycle-Pyridine series;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivates;Chloropyridines;Halopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;amine| alkyl chloride;Bromides;Pyridines;bc0001;1072-98-6
Mol File:1072-98-6.mol
2-Amino-5-chloropyridine Structure
2-Amino-5-chloropyridine Chemical Properties
Melting point 135-138 °C (lit.)
Boiling point 127-128 °C/11 mmHg (lit.)
density 1.2417 (rough estimate)
refractive index 1.5110 (estimate)
Fp 160 °C
storage temp. 2-8°C
solubility 1.0g/l
pka4.67±0.13(Predicted)
form Crystalline Powder
color Beige to beige-brown
Water Solubility 1 g/L (20 ºC)
BRN 108735
InChIKeyMAXBVGJEFDMHNV-UHFFFAOYSA-N
CAS DataBase Reference1072-98-6(CAS DataBase Reference)
NIST Chemistry Reference2-Amino-5-chloropyridine(1072-98-6)
EPA Substance Registry System2-Amino-5-chloropyridine (1072-98-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 22-24/25-37/39-26-36
WGK Germany 3
Hazard Note Harmful
HazardClass IRRITANT
HS Code 29333999
MSDS Information
ProviderLanguage
2-Amino-5-chloropyridine English
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ACROS English
ALFA English
2-Amino-5-chloropyridine Usage And Synthesis
Chemical Propertiesbeige to beige-brown crystalline powder
Uses5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.
Synthesis Reference(s)The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020
Purification MethodsRecrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]
2-Amino-5-chloropyridine Preparation Products And Raw materials
Preparation ProductsZopiclone-->2,5-Dichloropyridin-3-amine-->2,5-Dichloro-3-nitropyridine-->5-Chloro-2-hydroxy-3-nitropyridine-->ethyl 2-(6-aminopyridin-3-yl)acetate-->6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine-->EthanediaMide iMpurity F-->2-Bromo-5-chloropyridine-->2-BROMO-5-CHLORO-3-NITROPYRIDINE-->2-Amino-5-chloro-3-nitropyridine-->3-AMINO-2-BROMO-5-CHLOROPYRIDINE-->5-Chloropyridine-2-carboxylic acid
2-AMINO-3,5-DICHLORO-4-METHYLPYRIDINE 2-Amino-5-chloropyridine 4-(5-CHLORO-2-PYRIDYLAZO)-1,3-PHENYLENEDIAMINE 2-Chloro-3-cyanopyridine ALTRENOGEST 3-Aminopyridine 6-Aminocaproic acid Glycine Pentachloropyridine 3-CHLOROPYRIDINE-2,6-DIAMINE 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]-1-METHYLHYDRAZINE Clopidol 2-Amino-5-chloro-3-nitropyridine 2-Aminopyridine 2-Aminophenol Tris(hydroxymethyl)aminomethane AMINO ACIDS 4-Dimethylaminopyridine
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