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| | 15(S)-HETE Basic information |
| Product Name: | 15(S)-HETE | | Synonyms: | (15s,5z,8z,11z,13e)-15-hydroxyeicosatetraenoic acid;(5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid;Icomucret;(5Z,8Z,11Z,13E,15S)-15-Hydroxy-5,8,11,13-icosatetraenoic acid;(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate;(15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate;C04742;15(S)-HETE Lipid Maps MS Standard | | CAS: | 54845-95-3 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 54845-95-3.mol |  |
| | 15(S)-HETE Chemical Properties |
| Boiling point | 487.7±45.0 °C(Predicted) | | density | 0.984±0.06 g/cm3(Predicted) | | Fp | 14℃ | | storage temp. | -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | | pka | 4.75±0.10(Predicted) | | form | Liquid. | | BRN | 2470466 |
| | 15(S)-HETE Usage And Synthesis |
| Description | 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis. | | Uses | 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis. | | Uses | 15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity. | | Definition | ChEBI: An optically active form of 15-HETE having 15(S)-configuration.. | | General Description | 15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ). | | Biochem/physiol Actions | Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2. |
| | 15(S)-HETE Preparation Products And Raw materials |
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