ChemicalBook Product Catalog API Hormones and the Endocrine System Prostaglandin drugs Misoprostol Acid

Misoprostol Acid

Misoprostol Acid Basic information
Product Name:Misoprostol Acid
Synonyms:MISOPROSTOL FREE ACID;(+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1;(11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid;(-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E;MISOPROSTOL ACID;(+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E1;Misoprostol free acid,(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1;Misoprostol Acid (10 mg in 1 mL Methyl Acetate)
CAS:112137-89-0
MF:C21H36O5
MW:368.51
EINECS:
Product Categories:Active Pharmaceutical Ingredients;Fatty Acid Derivatives & Lipids;Glycerols;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:112137-89-0.mol
Misoprostol Acid Structure
Misoprostol Acid Chemical Properties
Boiling point 538.3±50.0 °C(Predicted)
density 1.118±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform
form Yellow viscous oil.
pka4.77±0.10(Predicted)
color Pale Yellow
Stability:Temperature Sensitive
Safety Information
Hazard Codes T
Risk Statements 45-60-61-25-36/37/38
Safety Statements 53-22-36/37/39-45-26
RIDADR UN 2810 6.1/PG 3
WGK Germany 2
HazardClass 6.1
MSDS Information
Misoprostol Acid Usage And Synthesis
DescriptionMisoprostol is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.
Chemical PropertiesPale Yellow Gel
UsesMisoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.
UsesA metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration
UsesA cytoprotective prostaglandin PGE1 analogue.
Biochem/physiol ActionsMisoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent.
Misoprostol Acid Preparation Products And Raw materials
Latanoprost PROSTAGLANDIN F1ALPHA LEUKOTRIENE D4 LEUKOTRIENE B4 DIMETHYL AMIDE 11BETA-PROSTAGL AND IN F2ALPHA 13,14-DIHYDROPROSTAGLANDIN E1 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID PROSTAGLANDIN D2 L-161,982 Prostaglandin F2a Fluprostenol PROSTAGLANDIN B1 Mexiprostil Misoprostol Acid MISOPROSTOL MISOPROSTOL-D4 (+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1 Misoprostol acid-d5
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