ChemicalBook Product Catalog Pharmaceutical intermediates Bulk Drug Intermediates Potassium di-tert-butyl phosphate

Potassium di-tert-butyl phosphate

Potassium di-tert-butyl phosphate Basic information
Product Name:Potassium di-tert-butyl phosphate
Synonyms:DI-TERT-BUTYLPHOSPHATE, POTASSIUM SALT;DI-TERTIARYBUTYL PHOSPHATE (POTASSIUM SALT);Di-t-butyl phosphate, potassium salt;Nsc264063;Potassium di-t-butylphosphate, min. 91% (contains <5% water);Di-tert-butyl phosphate;POTASSIUM DI-TERT-BUTYLPHOSPHATE;bis(tert-butoxy)phosphinic acid potassium hydride
CAS:33494-80-3
MF:C8H20KO4P
MW:250.32
EINECS:619-702-9
Product Categories:
Mol File:33494-80-3.mol
Potassium di-tert-butyl phosphate Structure
Potassium di-tert-butyl phosphate Chemical Properties
Melting point 247-252°C
storage temp. 2-8°C
form Powder
color white
InChIKeyZSWXMOQFFWMZQH-UHFFFAOYSA-M
CAS DataBase Reference33494-80-3
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
TSCA No
HS Code 2919900090
MSDS Information
Potassium di-tert-butyl phosphate Usage And Synthesis
UsesDi-tert-butylphosphate Potassium Salt is a catalyst used in organic synthesis. Also used in the preparation of HIV attachment inhibitor BMS-663068.
ApplicationUtilized as an intermediate to prepare N-phosphonooxymethyl prodrugs, which increase bioavailability, and to prepare Nasicon-type phosphates (i.e., KTi2(PO4)3) used in fast ion conductors with low thermal expansion ceramics.appl
PreparationPotassium di-tert-butyl phosphate synthesis: Di-tert-butyl phosphite (40.36 mmol) was combined with potassium bicarbonate (24.22 mmol) in 35 ml of water. The solution was stirred in an ice bath and potassium permanganate (28.25 mmole) was added in three equal portions over a period of one hour. The reaction was then allowed to continue for another half hour at room temperature. Decolorizing carbon (600 mg) was then incorporated as the reaction was heated to 60 °C for 15 min. The reaction was then vacuum filtered to remove solid magnesium dioxide. The solid was washed several times with water. The filtrate was then combined with one gram of decolorizing carbon and heated at 60°C for another twenty minutes. The solution was filtered again to give a colorless solution, which was then evaporated in vacuo to give the crude potassium di-tert-butyl phosphate salt.
Flammability and ExplosibilityNonflammable
Potassium di-tert-butyl phosphate Preparation Products And Raw materials
Raw materialsDI-TERT-BUTYL PHOSPHITE-->Potassium bicarbonate-->Decolorizing charcoal
Triisobutyl phosphate DI-TERT-BUTYL PHOSPHITE Potassium di-tert-butyl phosphate Dibutyl phosphate Potassium iodide Potassium sorbate Tributyl phosphate Di-tert-butyl dicarbonate Trisodium phosphate Potassium lactate DI-T-BUTYL PHOSPHORIC ACID Potassium persulfate Potassium Citrate phosphate Potassium chlorate Potassium Acetate Potassium chloride Potassium
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