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| | Ethyl carbazate Basic information |
| | Ethyl carbazate Chemical Properties |
| Hazard Codes | Xi,T | | Risk Statements | 36/37/38-25 | | Safety Statements | 26-36-45 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | FE2545000 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29280090 |
| | Ethyl carbazate Usage And Synthesis |
| Chemical Properties | Off-white crystals. | | Uses | Prepare 4-phenylurazole from ethyl carbazate and then oxidize the urazole with gaseous dinitrogen tetroxide to yield 4-phenyl-1,2,4-tri- azoline-3,5-dione la. Modification of the ethyl carbazate procedure in which analytically pure monoalkylhydrazine hydrochlorides were isolated in greater than 90% yield, starting from a ketone or aldehyde. Treatment of primary amines is with chloroamine or hydroxylamine-0-sulfonic acid and the condensation of a carbonyl compound with ethyl carbazate. The FeCl 3 -catalyzed reaction of ethyl carbazate (2 b) proceeded readily to give β-hydroxyester 3 b in better yield. A new one-pot neat synthesis of some 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones through cyclocondensation of ethyl carbazate with aryl nitriles catalyzed by DMAP as an efficient and basic nucleophilic catalyst is described. | | Uses | Synthetic intermediate. | | Hazard | Irritant. | | Purification Methods | Fractionate the carbazate using a Vigreux column (p 11) until the distillate crystallises [Allen & Bell Org Synth Coll Vol III 404 1955, Beilstein 3 IV 174]. |
| | Ethyl carbazate Preparation Products And Raw materials |
| Raw materials | Diethyl carbonate-->HYDRAZINE-->Methyl carbazate | | Preparation Products | 4-(1,2,3-THIADIAZOL-4-YL)BENZOYL CHLORIDE-->4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE-->5-CYANO-4-METHYL-1,2,3-THIADIAZOLE-->4-(4-CHLOROPHENYL)-1,2,3-THIADIAZOL-5-AMINE-->4-PHENYL-1,2,3-THIADIAZOL-5-AMINE-->4-(1,2,3-THIADIAZOL-4-YL)BENZALDEHYDE-->Thidiazuron-->4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE-->4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE-->4-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,3-THIADIAZOL-5-AMINE-->4-Methyl-1,2,3-thiadiazole-5-carboxylic acid-->4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE-->4-(1,2,3-THIADIAZOL-4-YL)BENZOIC ACID-->4-(1,2,3-THIADIAZOL-4-YL)PHENOL-->4-(1,2,3-THIADIAZOL-4-YL)ANILINE-->4-ISOPROPYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID-->4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE-->(1,2,3-THIADIAZOL-4-YL)METHANOL-->4-(4-NITROPHENYL)-1,2,3-THIADIAZOLE-->4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOLE-->4-(1,2,3-THIADIAZOL-4-YL)BENZONITRILE-->4-(4-CHLOROPHENYL)-1,2,3-THIADIAZOLE-->4-(4-BROMOPHENYL)-1,2,3-THIADIAZOLE-->4-METHYL-1,2,3-THIADIAZOLE-5-CARBONYL CHLORIDE-->ETHYL 4-ISOPROPYL-1,2,3-THIADIAZOLE-5-CARBOXYLATE-->1,2,3-THIADIAZOLE-4-CARBOXYLIC ACID-->1,2,3-Thiadiazole-4-carbonyl chloride (6CI,7CI,8CI,9CI)-->ETHYL 4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXYLATE-->ETHYL 1,2,3-THIADIAZOLE-4-CARBOXYLATE-->Cadralazine |
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