ChemicalBook Product Catalog Organic Chemistry Organometalate Sodium dichloroacetate

Sodium dichloroacetate

Sodium dichloroacetate Basic information
Uses
Product Name:Sodium dichloroacetate
Synonyms:dichloroacetate,sodiumsalt;dichloro-aceticacisodiumsalt;dichloroctansodny;Sodiumdichloracetate;NATRIUMDICHLORACETAT;SDA;SODIUM DICHLOROACETATE;erlcyiuanna
CAS:2156-56-1
MF:C2H3Cl2NaO2
MW:152.93
EINECS:218-461-3
Product Categories:
Mol File:2156-56-1.mol
Sodium dichloroacetate Structure
Sodium dichloroacetate Chemical Properties
Melting point 198 °C (dec.) (lit.)
storage temp. Inert atmosphere,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form Powder
color White
PH6.0 to 8.5(50g/L, 25 ℃)
Water Solubility soluble in cold water
Sensitive Moisture Sensitive
Stability:Hygroscopic
InChIKeyLUPNKHXLFSSUGS-UHFFFAOYSA-M
CAS DataBase Reference2156-56-1(CAS DataBase Reference)
EPA Substance Registry SystemSodium dichloroacetate (2156-56-1)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-40
Safety Statements 26-37/39-36-36/37
RIDADR 2811
WGK Germany 2
RTECS AG9275000
HS Code 29154000
MSDS Information
ProviderLanguage
Dichloroacetic acid sodium salt English
SigmaAldrich English
ACROS English
ALFA English
Sodium dichloroacetate Usage And Synthesis
Uses

Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic. Recent studies had found that DCA acts as a potential vasoprotective agent by inhibiting PDK2 and reducing coronary endarterium proliferation. Further, DCA promotes brain regeneration after cerebral ischemia, which indicates that DCA might play an important role in VD.

Chemical Propertieswhite powder
UsesTreatment of neurologic injury (pyruvate dehydrogenase activator).
UsesSodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.
Brand nameCeresine (Cypros).
General DescriptionSodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.
Biological ActivityInhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo .
storageDesiccate at RT
Sodium dichloroacetate Preparation Products And Raw materials
Raw materialsDichloroacetic acid
Sodium dichloroacetate Sodium benzoate Sodium acetate SODIUM TRICHLOROACETATE sodium Sodium chloride Trisodium phosphate Dichloroacetic acid methyl ester Diclofenac sodium Dichloroacetic acid Dichloroacetate Sodium citrate Sodium bicarbonate Sodium hydroxide 2,2-DICHLOROPROPIONIC ACID SODIUM SALT Sodium chlorite 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Sodium chloroacetate
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