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| | 4-Cyanopyridine Basic information |
| | 4-Cyanopyridine Chemical Properties |
| Melting point | 76-79 °C(lit.) | | Boiling point | 196 °C | | density | 1.1145 (rough estimate) | | vapor pressure | 41.9Pa at 25℃ | | refractive index | 1.5242 (estimate) | | Fp | 88 °C | | storage temp. | Sealed in dry,Room Temperature | | solubility | 40g/l | | pka | pK1:1.90(+1) (25°C) | | form | Crystals or Powder | | color | White to off-white | | Water Solubility | 3.2 g/100ml (16.4 ºC) | | BRN | 107712 | | Exposure limits | NIOSH: IDLH 25 mg/m3 | | Stability: | Stable. Incompatible with strong bases, strong oxidizing agents, strong acids. | | InChIKey | GPHQHTOMRSGBNZ-UHFFFAOYSA-N | | LogP | 0.46 at 25℃ | | CAS DataBase Reference | 100-48-1(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Pyridinecarbonitrile(100-48-1) | | EPA Substance Registry System | 4-Pyridinecarbonitrile (100-48-1) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36/37-24/25 | | RIDADR | 3276 | | WGK Germany | 3 | | TSCA | Yes | | PackingGroup | III | | HS Code | 29333999 |
| | 4-Cyanopyridine Usage And Synthesis |
| Chemical Properties | beige solid | | Chemical Properties | The cyanopyridines are as follows: 2-cyano-:
A white to tan liquid or solid. Almond odor. Boiling
point=2213℃
; freezing/melting point=27℃
; flash
point=89℃
. 3-cyano-: a colorless liquid or gray crystal-
line solid. | | Uses | 4-Cyanopyridine is used as an intermediate in organic synthesis and pharmaceutical substances like isonicotinylhydrazide, which is used in the treatment of tuberculosis. It is used as a precursor for the preparation of isonicotinic acid and 4-diemthylaminopyridine (DMAP). It is involved in the synthesis of 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine by reacting with acetonitrile. | | Potential Exposure | Limits in Air
NIOSH IDLH525 mg/m3
NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not
to be exceeded in any 15-minute work period. | | Shipping | UN3276 Nitriles, liquid, toxic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required, Potential Inhalation Hazard (Special
Provision 5). | | Incompatibilities | Oxidizing agents, such as perchlorates,
peroxides, and permanganates. Nitriles may polymerize in
the presence of metals and some metal compounds. They
are incompatible with acids; mixing nitriles with strong
oxidizing acids can lead to extremely violent reactions.
Nitriles are generally incompatible with other oxidizing
agents such as peroxides and epoxides. The combination of
bases and nitriles can produce hydrogen cyanide. Nitriles
are hydrolyzed in both aqueous acid and base to give car-
boxylic acids (or salts of carboxylic acids). These reactions
generate heat. Peroxides convert nitriles to amides. Nitriles
can react vigorously with reducing agents. Acetonitrile and
propionitrile are soluble in water, but nitriles higher than
propionitrile have low aqueous solubility. They are also
insoluble in aqueous acids
. |
| | 4-Cyanopyridine Preparation Products And Raw materials |
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