5-Amino-2-chloropyridine

5-Amino-2-chloropyridine Basic information

Product Name:	5-Amino-2-chloropyridine
Synonyms:	3-PYRIDINAMINE, 6-CHLORO-;3-AMINO-6-CHLOROPYRIDINE;6-CHLOROPYRIDIN-3-AMINE;6-CHLORO-PYRIDIN-3-YLAMINE;5-AMINO-2-CHLOROPYRIDINE;2-CHLORO-5-AMINOPYRIDINE;TIMTEC-BB SBB004234;AMINO CHLOROPYRIDINE
CAS:	5350-93-6
MF:	C5H5ClN2
MW:	128.56
EINECS:	226-322-3
Product Categories:	Chloropyridines;Halopyridines;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PYRIDINE;Amines;blocks;Pyridines;pyridine derivative;Pyridine Series;Pyridines derivates;Amino-pyridine series;compounds of pyridine;bc0001
Mol File:	5350-93-6.mol

5-Amino-2-chloropyridine Chemical Properties

Melting point	81-83 °C(lit.)
Boiling point	205.39°C (rough estimate)
density	1.2417 (rough estimate)
refractive index	1.5110 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	1.94±0.10(Predicted)
form	powder to crystal
color	White to Brown
BRN	108891
InChIKey	QAJYCQZQLVENRZ-UHFFFAOYSA-N
CAS DataBase Reference	5350-93-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333999

MSDS Information

Provider	Language
5-Amino-2-chloropyridine	English
SigmaAldrich	English
ACROS	English
ALFA	English

5-Amino-2-chloropyridine Usage And Synthesis

Chemical Properties	Light yellow to brown crystalline powder
Uses	5-Amino-2-chloropyridine was used in the synthesis of [²H₅]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals.
Definition	ChEBI: 3-Amino-6-chloropyridine is an aminopyridine.
General Description	5-Amino-2-chloropyridine undergoes Suzuki-Miyaura coupling with sterically hindered 2,6-dimethylphenylboronic acid. It undergoes facile temperature dependent displacement of chloride by bromide via Sandmeyer reaction to yield 2,5-dibromopyridine.

5-Amino-2-chloropyridine Preparation Products And Raw materials

Raw materials

6-Chloronicotinamide-->2-Chloro-5-iodopyridine-->2-Chloro-5-nitropyridine-1-oxide-->Boron trifluoride methyl sulfide complex-->2-Amino-5-fluoropyridine-->2-Chloro-5-nitropyridine

Preparation Products

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID-->5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID-->5-AMINOPYRIDINE-2-BORONIC ACID PINACOL ESTER-->5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE-->2-Chloro-5-fluoropyridine-->3-Aminopyridine-->3-Amino-6-hydroxypyridine-->3-Pyridinamine,6-chloro-N-methyl-(9CI)-->ethyl 4,6-dichloro-1,5-naphthyridine-3-carboxylate-->3-amino-6-chloro-1H-pyridine-2-thione

2,6-Dichloropyridin-3-amine 5-Amino-2-chloropyridine 2-CHLORO-4,6-DIMETHYL-5-NITRO-NICOTINONITRILE 2-Chloro-5-chloromethylpyridine 2-CHLORO-5-NITRO-6-(3-NITROPHENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE ALTRENOGEST 3-Aminopyridine 6-Aminocaproic acid Glycine ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE 2-CHLORO-6-METHYL-5-NITRO-4-(TRIFLUOROMETHYL)NICOTINONITRILE Clopidol 2-AMINO-6-CHLORO-3-NITROPYRIDINE 2-Chloro-3-methyl-5-nitropyridine Tris(hydroxymethyl)aminomethane AMINO ACIDS 3-Aminophenol 4-Dimethylaminopyridine

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