(R)-(-)-2-PHENYLBUTYRIC ACID

(R)-(-)-2-PHENYLBUTYRIC ACID Basic information
Product Name:(R)-(-)-2-PHENYLBUTYRIC ACID
Synonyms:(R)-(-)-alpha-Ethylphenylaceticacid;(R)-(-)-2-Phenylbutyricacid,98+%;(r)-(-)-à-ethylphenylacetic acid;(2R)-2-Phenylbutanoic acid;(2R)-2-Phenylbutyric acid;(αR)-α-Ethylbenzeneacetic acid;(R)-(-)-2-Phenylbutyric acid,99%;(R)-(-)-2-Phenylbutyric acid, 99% 1GR
CAS:938-79-4
MF:C10H12O2
MW:164.2
EINECS:
Product Categories:Carboxylic Acids;Chiral Building Blocks;Organic Building Blocks
Mol File:938-79-4.mol
(R)-(-)-2-PHENYLBUTYRIC ACID Structure
(R)-(-)-2-PHENYLBUTYRIC ACID Chemical Properties
alpha [α]D20 -92~-98゜ (c=4, C6H5CH3)
Boiling point 102-104 °C/0.4 mmHg (lit.)
density 1.055 g/mL at 25 °C (lit.)
refractive index n20/D 1.516
Fp >230 °F
storage temp. Refrigerator
solubility Chloroform (Slightly), Ethanol (Slightly), Toluene (Slightly)
form Liquid
color Clear colorless
optical activity[α]20/D 93°, c = 0.9 in toluene
BRN 2327346
CAS DataBase Reference938-79-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 23-36
WGK Germany 3
HS Code 29163900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
(R)-(-)-2-PHENYLBUTYRIC ACID Usage And Synthesis
Chemical Propertiesclear colorless liquid
Uses(R)-(-)-2-Phenylbutyric Acid, is the metabolite of Butamirate (B690025), which is a novel antitussive drug.
Purification MethodsPurify the acids by distillation at atmospheric pressure using an efficient column. The acid chlorides have b 106-107o/20mm, []D () and (+) 108o (c 2, *C6H6). [Levene et al. J Biol Chem 100 589 1933, Gold & Aubert Helv Chim Acta 41 1512 1958, ORD in heptane: Rothen & Levene J Chem Phys 7 975 1939, Beilstein 9 III 2461.]
(R)-(-)-2-PHENYLBUTYRIC ACID Preparation Products And Raw materials
Raw materials(E)-2-Phenyl-2-butenoic acid-->2-PHENYLBUTYRIC ACID ANHYDRIDE-->Phenylacetyl chloride-->2-Phenylbutyric acid
Preparation Products(S)-(+)-2-PHENYLBUTYRIC ACID
FMOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID [R,(-)]-3-Methyl-2-phenylbutyric acid (S)-4-AMINO-3-PHENYLBUTANOIC ACID FMOC-(S)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID (S)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE BOC-(S)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID (S)-2-Hydroxy-2-phenylbutyric acid [S,(+)]-2-Methyl-4-phenylbutyric acid ethyl ester BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID rac-(2R*)-2-Amino-2-phenylbutyric acid FMOC-(S)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID FMOC-(R)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID 2-Phenylbutyric acid ethyl ester FMOC-(S)-3-AMINO-4-(4-NITRO-PHENYL)-BUTYRIC ACID BOC-(R)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID (3R)-3-Phenylbutyric acid BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID FMOC-(S)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID

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