BENFLUOREX HYDROCHLORIDE

BENFLUOREX HYDROCHLORIDE Basic information
Product Name:BENFLUOREX HYDROCHLORIDE
Synonyms:benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester;Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, benzoate;jp992;Minolip;n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-phenethylaminbenzoate;N-(2-Hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylamine benzoate;n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylaminebenzoate;Phenethylamine, N-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-, benzoate
CAS:23602-78-0
MF:C19H20F3NO2
MW:351.36
EINECS:245-777-9
Product Categories:MINOLIP
Mol File:23602-78-0.mol
BENFLUOREX HYDROCHLORIDE Structure
BENFLUOREX HYDROCHLORIDE Chemical Properties
Boiling point 420.5±45.0 °C(Predicted)
density 1.183±0.06 g/cm3(Predicted)
pka8.23±0.10(Predicted)
Safety Information
WGK Germany 2
RTECS KL8275000
ToxicityLD50 oral in mouse: 2300mg/kg
MSDS Information
BENFLUOREX HYDROCHLORIDE Usage And Synthesis
OriginatorMediator,Servier,France,1976
Usesantihyperlipoproteinemic
DefinitionChEBI: Benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester is a benzoate ester.
Manufacturing ProcessTo a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β- hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were added successively 15 parts of 4.7N hydrochloric ether and a solution of 14 parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from 230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)- 2-(β-benzoyloxyethyl)amino propane hydrochloride melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts ether are added, then 10 parts of a concentrated solution of ammonium hydroxide. The mixture is stirred a few minutes until the salt is dissolved, then the ethered solution is poured off and dried. After the ether is eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β- benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.

Therapeutic FunctionAntihyperlipidemic, Cardiovascular
BENFLUOREX HYDROCHLORIDE Preparation Products And Raw materials
Raw materialsBenzoyl chloride
Pentafluorophenol Florfenicol Powder Benzotrifluoride Rimonabant Diphenhydramine ZINC TELLURIDE Florfenicol Pentafluorobenzoic acid 1-(3-methylphenyl)propan-2-amine BENFLUOREX HYDROCHLORIDE FENFLURAMINE Ethanolamine benzoate hydrochloride, 98+% FENFLURAMINE HYDROCHLORIDE METHYL-(2-M-TOLYL-ETHYL)-AMINE BENFLUOREX HYDROCHLORIDE Norfenfluramine 5-Pyridin-2-yl-1H-pyrazole-3-carboxylic acid

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