2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE

2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE Basic information
Product Name:2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE
Synonyms:BUTTPARK 33\04-80;2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE;4-(Trifluoromethyl)quinolin-2-ol;4-Trifluoromethyl-1H-quinolin-2-one;2-Hydroxy-4-(trifluoromethyl)quinoline ,98%;4-(trifluoromethyl)quinolin-2(1H)-one;2-hydroxy-4-(trifluoroMethyl)quinqline;4--(TrifluoroMethyl)quinoline-2(H)-one
CAS:25199-84-2
MF:C10H6F3NO
MW:213.16
EINECS:
Product Categories:
Mol File:25199-84-2.mol
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE Structure
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE Chemical Properties
Melting point >240°C
Boiling point 284 ºC
density 1.391
Fp 126 ºC
storage temp. Sealed in dry,Room Temperature
form Solid
color White
InChIInChI=1S/C10H6F3NO/c11-10(12,13)7-5-9(15)14-8-4-2-1-3-6(7)8/h1-5H,(H,14,15)
InChIKeyUUROBWTVZZNDFD-UHFFFAOYSA-N
SMILESN1C2=C(C=CC=C2)C(C(F)(F)F)=CC1=O
CAS DataBase Reference25199-84-2
Safety Information
Safety Statements 24/25
HS Code 29339900
MSDS Information
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE Usage And Synthesis
Chemical PropertiesWhite solid
Synthesis4-Trifluoromethylquinolin-2(1H)-one was prepared by reacting aniline and ethyl-4,4,4-trifluoroacetoacetate stirred in toluene.
Experimental Procedure: In a 1 L round flask fitted with a reflux condenser a mixture of 25.60 g aniline, 50.0 g ethyl-4,4,4-trifluoroacetoacetate 300 ml toluene was heated to reflux in an oil bath at 130 °C. After 20 min 3 ml water was added and the mixture was heated at reflux for another 24 h. the reaction mixture was cooled to room temperature and concentrated under reduced pressure. A round flask with 200 mL H2SO4 was heated to 80°C and the crude oil from the step before was added in portions to the H2SO4 keeping the internal temperature below 90°C, total addition time was approximately 40 min. After addition was complete, the mixture was stirred at 80°C for 1 h, cooled and poured onto 400 g crushed ice. The resulting solids were filtered, washed with water, and dried under vacuum at 40°C to give 33.0 g (50%) product (4-Trifluoromethylquinolin-2(1H)-one) as a colorless solid.
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE Preparation Products And Raw materials
Raw materialsSulfuric acid-->Ethyl 4,4,4-trifluoroacetoacetate-->4-Fluoroaniline-->4,4,4-trifluoro-3-oxo-N-phenylbutanamide-->Aniline
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE 2-CHLOROTHIOPHENOL 4-Aminobenzotrifluoride 3-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzoic acid AURORA KA-5337 BUTTPARK 52\04-85 AURORA KA-5338 AURORA KA-5503 2-Quinolinol Trifluoromethyl 4-Trifluoromethylphenol 2,4-DIFLUOROPHENYL 8-METHYL-4-(TRIFLUOROMETHYL)-2-QUINOLINYL ETHER CHLOROPHOSPHONAZO III 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Quinhydrone 8-METHYL-4-(TRIFLUOROMETHYL)-2-QUINOLINYL 3-(TRIFLUOROMETHYL)PHENYL ETHER 2-Methylbenzotrifluoride

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