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| | 2-Fluorophenol Basic information |
| | 2-Fluorophenol Chemical Properties |
| Melting point | 16.1 °C (lit.) | | Boiling point | 171-172 °C/741 mmHg (lit.) | | density | 1.256 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.511(lit.) | | Fp | 116 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | 37.7g/l | | form | Liquid | | pka | 8.73(at 25℃) | | color | Clear colorless to light yellow-brownish | | Specific Gravity | 1.256 | | Water Solubility | 80.72g/L(25 ºC) | | BRN | 1905112 | | Stability: | Stable. Flammable. Incompatible with strong oxidizing agents. | | InChIKey | HFHFGHLXUCOHLN-UHFFFAOYSA-N | | CAS DataBase Reference | 367-12-4(CAS DataBase Reference) | | NIST Chemistry Reference | Phenol, 2-fluoro-(367-12-4) | | EPA Substance Registry System | o-Fluorophenol (367-12-4) |
| | 2-Fluorophenol Usage And Synthesis |
| Chemical Properties | Clear colourless to yellow liquid | | Uses | 2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria. | | Synthesis Reference(s) | Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015 | | General Description | Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3. | | Air & Water Reactions | Highly flammable. | | Reactivity Profile | 2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid. | | Health Hazard | ACUTE/CHRONIC HAZARDS: Toxic and irritant. | | Purification Methods | Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.] |
| | 2-Fluorophenol Preparation Products And Raw materials |
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