| | CLOTIAZEPAM Basic information |
| Product Name: | CLOTIAZEPAM | | Synonyms: | CLOTIAZEPAM;2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-;2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-;2h-thieno(2,3-e)(1,4)diazepin-2-one,1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-m;2h-thieno(2,3e)(1,4)-diazepin-2-one,5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1;2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-;2H-Thieno[2,3-E]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-;5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno(2,3-e)(1,4)diazepi | | CAS: | 33671-46-4 | | MF: | C16H15ClN2OS | | MW: | 318.82 | | EINECS: | 251-627-3 | | Product Categories: | Agonist;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds | | Mol File: | 33671-46-4.mol |  |
| | CLOTIAZEPAM Chemical Properties |
| Melting point | 105-106° | | Boiling point | 523.7±50.0 °C(Predicted) | | density | 1.1625 (rough estimate) | | refractive index | 1.6100 (estimate) | | solubility | DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | | form | A crystalline solid | | pka | 2.36±0.20(Predicted) |
| Toxicity | LD50 in mice (mg/kg): 440 i.p., 636 orally (Nakanishi) |
| | CLOTIAZEPAM Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Originator | Rize,Yoshitomi,Japan,1979 | | Uses | A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be
nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor.
Controlled Substance. | | Definition | ChEBI: Clotiazepam is an organic molecular entity. | | Manufacturing Process | To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of
acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a
flask provided with a water-removing adaptor. The reaction mixture is
concentrated, and the residue is extracted with chloroform. The chloroform
layer is washed with water and then with a sodium hydrogen carbonate
solution, then dried over magnesium sulfate. The chloroform is distilled off
under reduced pressure, and toluene is added to the residue. Thus is
precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro-
3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C. | | Therapeutic Function | Tranquilizer |
| | CLOTIAZEPAM Preparation Products And Raw materials |
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