(2R,3R)-2-Amino-3-methylpentanoic acid

(2R,3R)-2-Amino-3-methylpentanoic acid Basic information
Product Name:(2R,3R)-2-Amino-3-methylpentanoic acid
Synonyms:(2R,3R)-2-Amino-3-methylvaleric acid;D-Ile-OH;D-Isoleucine≥ 98% (TLC);D-Ile;D(-)-ISOLEUCINE;D-ISOLEUCINE;H-D-ILE-OH;[-]-2-AMINO-3-METHYLPENTANOIC ACID
CAS:319-78-8
MF:C6H13NO2
MW:131.17
EINECS:206-269-2
Product Categories:Amino Acid Derivatives;Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acids;bc0001
Mol File:319-78-8.mol
(2R,3R)-2-Amino-3-methylpentanoic acid Structure
(2R,3R)-2-Amino-3-methylpentanoic acid Chemical Properties
Melting point 272-274 °C
alpha -37 º (c=5, 1 N HCl 24 ºC)
Boiling point 225.8±23.0 °C(Predicted)
density 1.1720 (estimate)
refractive index -40.5 ° (C=4, 6mol/L HCl)
storage temp. Sealed in dry,Room Temperature
solubility Aqueous Acid (Slightly), Water (Slightly)
pka2.57±0.24(Predicted)
form Solid
color White to Off-White
CAS DataBase Reference319-78-8(CAS DataBase Reference)
EPA Substance Registry SystemD-Isoleucine (319-78-8)
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 24/25-36-22
WGK Germany 3
RTECS NR4700000
HS Code 29224995
Toxicityrat,LD50,intraperitoneal,6822mg/kg (6822mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)LUNGS, THORAX, OR RESPIRATION: DYSPNEA,Archives of Biochemistry and Biophysics. Vol. 64, Pg. 319, 1956.
MSDS Information
ProviderLanguage
(2R,3R)-2-Amino-3-methylpentanoic acid English
SigmaAldrich English
ACROS English
(2R,3R)-2-Amino-3-methylpentanoic acid Usage And Synthesis
Chemical Propertieswhite to very slightly yellow powder
UsesMay contain up to 10% allo-isomer.
UsesD-Isoleucine is not biosynthesized in the human body and is therefore categorized as an essential amino acid that must be obtained through diet. It is also an important building block that is used in the formation of hemoglobin in humans.
DefinitionChEBI: The D-enantiomer of isoleucine.
(2R,3R)-2-Amino-3-methylpentanoic acid Preparation Products And Raw materials
Raw materialsAcetic anhydride-->L-Isoleucine
Preparation ProductsL-Isoleucine-->Cyclo(Ile-Ala)
Boc-alpha-Cyclohexyl-D-glycine (2R,3R)-2-Amino-3-methylpentanoic acid BOC-D-ILE-OH 1/2H2O FMOC-D-ILE-OPFP FMOC-CHG-OH FMOC-D-CHG-OH Boc-D-Cyclopentylglycine FMOC-D-CPG-OH Boc-D-isoleucine BOC-D-(2-INDA)GLY-OH BOC-D-MELEU-OH Fmoc-D-Ile-OH (2R,3R)-2-ACETYLAMINO-3-METHYL-PENTANOIC ACID D-alpha-Cyclohexylglycine FMOC-D-IGL-OH Z-D-PHG-OH BOC-D-ILE 1/2 H2O (+/-)-1-AMINOCYCLOPENTANE-CIS-1,2-DICARBOXYLIC ACID

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