| Chemical Properties | Clear colorless liquid |
| Chemical Properties | Isopropyl palmitate is a clear, colorless to pale yellow-colored,
practically odorless viscous liquid that solidifies at less than 16°C. |
| Uses | Pharmaceutic aid (vehicle, oleaginous). |
| Uses | Isopropyl palmitate is used to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application and to characterize microemulsion systems of isopropyl palmitate, water and 2:1 Brij 97, and 1-butanol by different experimental techniques. |
| Uses | isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential. |
| Definition | ChEBI: A fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. |
| Production Methods | Isopropyl palmitate is prepared by the reaction of palmitic acid with
propan-2-ol in the presence of an acid catalyst. A high-purity
material is also commercially available, which is produced by
enzymatic esterification at low temperatures. |
| General Description | Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in Psidium salutare fruits and boiled buckwheat flour.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Pharmaceutical Applications | Isopropyl palmitate is a nongreasy emollient with good spreading
characteristics, used in topical pharmaceutical formulations and
cosmetics such as: bath oils; creams; lotions; make-up; hair care
products; deodorants; lip products; suntan preparations; and
pressed powders.
Isopropyl palmitate is an established penetration enhancer for
transdermal systems. It has also been used in controlled-release
percutaneous films.
Table I: Uses of isopropyl palmitate |
| Safety | Isopropyl palmitate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg |
| storage | Isopropyl palmitate is resistant to oxidation and hydrolysis, and
does not become rancid. It should be stored in a well-closed
container, above 16°C, and protected from light. |
| Regulatory Status | Included in the FDA Inactive Ingredients Database (topical and
transdermal preparations). Used in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients. |
