2-Bromo-2-methylpropionic acid

2-Bromo-2-methylpropionic acid Basic information

Product Name:	2-Bromo-2-methylpropionic acid
Synonyms:	2-BROMO-2-METHYLPROPIONIC ACID;2-BROMOISOBUTYRIC ACID;2-Bromo-2-methylpropanoic acid;2-bromo-2-methyl-propanoicaci;2-bromo-2-methyl-Propanoicacid;Isobromobutyric acid;Propanoic acid, 2-bromo-2-methyl-;Propionic acid, 2-bromo-2-methyl-
CAS:	2052-01-9
MF:	C4H7BrO2
MW:	167
EINECS:	218-139-2
Product Categories:	Building Blocks;C1 to C5;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Organic acids;ACID BASED BROMO COMPOUNDS;bc0001
Mol File:	2052-01-9.mol

2-Bromo-2-methylpropionic acid Chemical Properties

Melting point	44-47 °C(lit.)
Boiling point	198-200 °C(lit.)
density	1.43 g/cm3
refractive index	1.4570 (estimate)
Fp	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	soluble in Chloroform, Methanol
pka	2.91±0.10(Predicted)
form	Liquid
color	Clear colorless to slightly yellow
Water Solubility	Soluble in alcohol and ether. Slightly soluble in water.
Merck	14,1421
BRN	1745543
Stability:	Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference	2052-01-9(CAS DataBase Reference)
NIST Chemistry Reference	«alpha»-Bromoisobutyric acid(2052-01-9)
EPA Substance Registry System	Propanoic acid, 2-bromo-2-methyl- (2052-01-9)

Safety Information

MSDS Information

2-Bromo-2-methylpropionic acid Usage And Synthesis

Chemical Properties	white powder
Uses	2-Bromo-2-methylpropionic acid is used in the Herceptin functionalization of polyhedral oligomeric silsesquioxane-conjugated oligomers-silica /iron oxide nanoparticles for tumor cell sorting.
Uses	2-Bromoisobutyric acid is used in the synthesis of dextran macroinitiator for atom transfer radical polymerization (ATRP) by partial esterification of hydroxyl group of the polysaccharide. The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
General Description	The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.

2-Bromo-2-methylpropionic acid Preparation Products And Raw materials

Raw materials	2-(2-bromoisobutyryloxy)ethyl acrylate-->2-Bromoisobutyryl Bromide-->ISOBUTYRIC ACID POTASSIUM SALT-->PhosphonoMethanol-->2-Aminoisobutyric Acid-->Isobutyric acid-->3-HYDROXY-2,2-DIMETHYL-3-PHENYLPROPIONIC ACID, 99-->2-Hydroxyethyl acrylate-->Benzaldehyde
Preparation Products	2-MERCAPTOISOBUTYRIC ACID-->2-((Ethoxythioxo methyl)thio)-2-methylpropanoic acid-->1,2-DIBROMO-2-METHYLPROPANE-->2,2,3,3-TETRAMETHYLSUCCINIC ACID, 97-->Methyl 2-bromo-2-methylpropionate-->Bromoform-->2-(4-Chlorophenoxy)-2-methylpropionic acid-->Fenofibric acid

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