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| | CARBONIC ACID DI-2-PYRIDYL ESTER Basic information |
| | CARBONIC ACID DI-2-PYRIDYL ESTER Chemical Properties |
| Melting point | 90 °C | | Boiling point | 351.6±17.0 °C(Predicted) | | density | 1.307 | | Fp | 166.438℃ | | storage temp. | Inert atmosphere,2-8°C | | pka | 0.63±0.12(Predicted) | | form | powder to crystal | | color | White to Light yellow | | InChIKey | GCSAXWHQFYOIFE-UHFFFAOYSA-N | | CAS DataBase Reference | 1659-31-0(CAS DataBase Reference) |
| | CARBONIC ACID DI-2-PYRIDYL ESTER Usage And Synthesis |
| Chemical Properties | White to faint yellow crystalline powder | | Uses | Di-2-pyridyl carbonate is used as a coupling agent in the esterification of carboxylic acids (e.g. 3-Cyclohexenylcarboxylic acid [C988195]). Di-2-pyridyl carbonate is also used as a reagent to synthesize active carbonates (e.g. benzyl 2-pyridyl carbonate) and carbamates (e.g. 3-Pyridyl diethylcarbamate [P992950]). | | Preparation | A solution of phosgene (2.5 m in toluene, 2 mL, 5.0 mmol) was diluted with dichloromethane (8 mL) and then a solution of 2-pyridinol 853 (950 mg, 10 mmol) and triethylamine (1.214 g, 10.2 mmol) in dichloromethane (20 mL) was added at 0 ℃. The reaction mixture was stirred at 0℃ for 1 h, then washed with cold 5% NaHCO3 solution (20 mL) and cold saturated brine (20 mL), dried over MgSO4, and filtered. The filtrate was concentrated to dryness to give di-2-pyridyl carbonate, DPC, 725 (972 mg) in 90% yield. It was recrystallized from dichloromethane/petroleum ether (811 mg, 75%); mp 84–86℃. DPC has also been produced as its hydrochloride salt 877, in a more facile procedure on a larger scale, in 97% yield. |
| | CARBONIC ACID DI-2-PYRIDYL ESTER Preparation Products And Raw materials |
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