Dimethyl acetylsuccinate

Dimethyl acetylsuccinate Basic information
Product Name:Dimethyl acetylsuccinate
Synonyms:acetyl-butanedioicaciddimethylester;acetyl-butanedioicacidimethylester;ACETYLSUCCINIC ACID DIMETHYL ESTER;DMAS;DIMETHYL ACETYLSUCCINATE;BUTANEDIOIC ACID, ACETYL-DIMETHYL ESTER;BUTANDIOIC ACID ACETYL-DIMETHYLESTER;Doimethyl Acetylsuccinate
CAS:10420-33-4
MF:C8H12O5
MW:188.18
EINECS:233-897-4
Product Categories:Pharmaceutical Intermediates;C8 to C9;Carbonyl Compounds;Esters;bc0001
Mol File:10420-33-4.mol
Dimethyl acetylsuccinate Structure
Dimethyl acetylsuccinate Chemical Properties
Melting point 33 °C (lit.)
Boiling point 129-134 °C/12 mmHg (lit.)
density 1.16 g/mL at 25 °C (lit.)
vapor pressure 19.6Pa at 25℃
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
solubility 30g/l OECD Test Guideline 105
pka10.53±0.59(Predicted)
form Notspecified
color White or Colorless to Almost white or Almost colorless
explosive limit0.72-11.1%(V)
LogP0.69 at 35℃ and pH7
CAS DataBase Reference10420-33-4(CAS DataBase Reference)
EPA Substance Registry SystemButanedioic acid, acetyl-, dimethyl ester (10420-33-4)
Safety Information
WGK Germany 1
TSCA Yes
HS Code 2918.30.7000
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Dimethyl acetylsuccinate Usage And Synthesis
UsesDimethyl Acetylsuccinate was used in preparation of β-carbolines via diastereo- and enantioselective Bronsted acid catalyzed N-acyliminium cyclization cascades of tryptamines and keto acids/esters.
UsesDimethyl acetylsuccinate has been used in the synthesis of 2-oxofuro[2,3-b]pyrroles and 19-methyl-15-oxa-20-azatricyclo[12.3.3.0(1,14)]icos-18-en-18-carboxylates.
General DescriptionDimethyl acetylsuccinate undergoes sulfuric acid catalyzed Pechmann condensation with the corresponding resorcinol derivative to give 7-hydroxycoumarins.
Dimethyl acetylsuccinate Preparation Products And Raw materials
Preparation ProductsMethyl (6-chloro-7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetate
CALCIUM LEVULINATE BENZYL ACETOACETATE Methyl levulinate Dimethyl acetylsuccinate 2-CYCLOPROPANECARBONYL-SUCCINIC ACID DIETHYL ESTER Dimethyl acetamidomalonate Dacthal 2,5-dioxo-1,4-cyclohexanedicarboxylic acid dimethyl ester 4-OXOTETRAHYDROTHIOPHENE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER DIMETHYL 2-[(E)-3-(DIMETHYLAMINO)-2-PROPENOYL]SUCCINATE 2-BUTYRYL-SUCCINIC ACID DIETHYL ESTER 2-HEXANOYL-SUCCINIC ACID DIETHYL ESTER 2-HEPTANOYL-SUCCINIC ACID DIETHYL ESTER 2-PROPIONYL-SUCCINIC ACID DIETHYL ESTER DIMETHYL 2-([1-(4-METHOXYPHENYL)-1H-1,2,3-TRIAZOL-4-YL]CARBONYL)SUCCINATE MONO-METHYL SUCCINATE 2-(2,2-DIMETHYL-PROPIONYL)-SUCCINIC ACID DIETHYL ESTER 2-(3-METHYL-BUTYRYL)-SUCCINIC ACID DIETHYL ESTER

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