ChemicalBook Product Catalog Chemical Reagents Organic reagents Boric acid PYRIMIDIN-4-YLBORONIC ACID

PYRIMIDIN-4-YLBORONIC ACID

PYRIMIDIN-4-YLBORONIC ACID Basic information
Product Name:PYRIMIDIN-4-YLBORONIC ACID
Synonyms:PYRIMIDIN-4-YLBORONIC ACID;PyriMidin-4-boronic acid;Boronic acid,B-4-pyriMidinyl-;Pyrimidine-3-boronic acid;4-Boronopyrimidine;Pyrimidin-4-ylboronic Acid (~80%);Pyrimidine-4-boronic acid
CAS:852362-24-4
MF:C4H5BN2O2
MW:123.91
EINECS:
Product Categories:Pyridines
Mol File:852362-24-4.mol
PYRIMIDIN-4-YLBORONIC ACID Structure
PYRIMIDIN-4-YLBORONIC ACID Chemical Properties
Melting point >205°C (dec.)
Boiling point 334.7±34.0 °C(Predicted)
density 1.33
storage temp. Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka6.86±0.53(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
PYRIMIDIN-4-YLBORONIC ACID Usage And Synthesis
UsesPyrimidin-4-ylboronic Acid is an intermediate used to prepare aldosterone synthase inhibiting pyrimidinylnaphthalenes via Suzuki cross-coupling reactions. It is also used in the synthesis of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine as a potent, orally active Src kinase inhibitor with antitumor activity.
PYRIMIDIN-4-YLBORONIC ACID Preparation Products And Raw materials
PYRIMIDIN-4-YLBORONIC ACID 2-(METHYLTHIO)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE 2-METHYLTHIO-6-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 4-CHLORO-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE 2-METHYLTHIO-6-CHLOROPYRIMIDINE-4-BORONIC ACID 2-CHLOROPYRIMIDIN-4-YL-4-BORONIC ACID 2-(1H-PYRAZOL-1-YL)-6-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 2-AMINO-6-CHLOROPYRIMIDIN-4-YL-4-BORONIC ACID 6-METHYL-2-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 6-CHLORO-2-AMINOPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 2-(PYRROLIDIN-1-YL)-6-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 2-MORPHOLINO-6-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 2-METHYLTHIO-6-METHYLPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 2-AMINO-6-METHYLPYRIMIDIN-4-YL-4-BORONIC ACID 2-CHLOROPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 6-CHLORO-2-METHYLPYRIMIDINE-4-BORONIC ACID PINACOL ESTER 6-CHLORO-2-METHYLPYRIMIDIN-4-YL-4-BORONIC ACID 6-CHLOROPYRIMIDIN-4-YL-4-BORONIC ACID
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