4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE

4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE Basic information
Product Name:4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE
Synonyms:4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE;4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one,97%;2-Oxazolin-5-one, 4-ethoxymethylene-2-phenyl-;(4E)-4-(Ethoxymethylene)-2-phenyl-1,3-oxazol-5(4H)-one;4-EthoxyMethelene-2-phenyloxazolin-5-one;4-EthoxyMethylene-2-phenyl-2-oxazolin-5-one purified by recrystallization;4-ETHOXYMETHYLENE-2-PHENYLOXAZOLIN-5-ONE;4-ETHOXYMETHYLENE-2-PHENYLOXAZOLINE-5-ONE
CAS:15646-46-5
MF:C12H11NO3
MW:217.22
EINECS:239-713-9
Product Categories:Building Blocks;Heterocyclic Building Blocks;API intermediates;Oxazolines/Oxazolidines
Mol File:15646-46-5.mol
4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE Structure
4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE Chemical Properties
Melting point 94-96 °C (dec.)(lit.)
Boiling point 357.77°C (rough estimate)
density 1.2160 (rough estimate)
refractive index 1.5560 (estimate)
storage temp. 2-8°C
form neat
pka-2.59±0.20(Predicted)
Water Solubility Soluble in methanol (50 mg/ml), and water (partly).
BRN 163055
CAS DataBase Reference15646-46-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 43
Safety Statements 36
WGK Germany 3
RTECS RQ5786250
HazardClass IRRITANT
HS Code 29349990
Toxicitymouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06780,
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE Usage And Synthesis
Chemical Propertieswhite to orange or pink powder
Uses4-Ethoxymethylene-2-phenyloxazolin-5-one acts as sensitizing agent. It is also used as pharmaceutical intermediates.
Uses4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one has been used as a haptenizing agent, which can induce an inflammatory reaction in adult zebrafish intestinal tissues and this can be used as a model for gene expression studies of the two forms of inflammatory bowel disease like Crohn′s disease and ulcerative colitis.
DefinitionChEBI: A 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position. It is a chemical allergen used for immunological experiments, particularly for experiments on delayed typ hypersensitivity.
4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE Preparation Products And Raw materials
3-ETHOXYACRYLIC ACID 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE Ethyl vinyl ether N-BENZYLIDENEMETHYLAMINE Methoxyethene 2-(BENZYLOXY)-ETHYLAMINE 4,5-DIHYDRO-2-PHENYLOXAZOLE beta-ethoxyacrolein ALLYL METHYL ETHER Ethyl propenyl ether 2-METHYL-2-OXAZOLINE 2-PHENYL-5-OXAZOLONE 2-Propenoic acid Ethyl acrylate 2-Ethoxyethylamine Allyl Benzyl Ether 3-METHOXYACROLEIN ACRYLATE, AMMONIUM

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