1-Methyl-4-pyrazole boronic acid pinacol ester

1-Methyl-4-pyrazole boronic acid pinacol ester Basic information

Product Name:	1-Methyl-4-pyrazole boronic acid pinacol ester
Synonyms:	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-;1-METHYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER;1-METHYL-4-(4,4,5,5-TERAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-methyl-4-(4，4，5，5-tetramethyl-1，3，2-dioxaborolan-2-yl)-1H-;1-Methyl-4-pyrazoleboronic acid pinacol ester, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Methyl-4-(4,4,5-trimethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+%;2-(1-Methylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS:	761446-44-0
MF:	C10H17BN2O2
MW:	208.07
EINECS:	616-293-9
Product Categories:	Boronate Esters;Boronic Acids and Derivatives;Chemical Synthesis;Heteroaryl Boronate Esters;Organometallic Reagents;Heterocyclic Building Blocks;Organoborons;Pyrazole;Boronic acid
Mol File:	761446-44-0.mol

1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties

Melting point	59-64 °C(lit.)
Boiling point	308.3±15.0 °C(Predicted)
density	1.05±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (slightly), Methanol (Slightly)
pka	2.09±0.10(Predicted)
form	Crystals
color	Off-white to yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey	UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES	N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference	761446-44-0(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

1-Methyl-4-pyrazole boronic acid pinacol ester Usage And Synthesis

Chemical Properties	White to light yellow crystal powde
Uses	1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for:Suzuki-Miyaura cross-coupling reactions ;Transesterification reactions Reagent used for preparation of• ;Aminothiazoles as γ-secretase modulators; ;Amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy;Pyridine derivatives as TGF-β1 and activin A signalling inhibitors;MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Uses	It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Uses	suzuki reaction

1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials	Tetrahydrofuran-->Potassium hydroxide-->n-Butyllithium-->Iodomethane-->Trimethyl borate-->Methyl bromide-->Pinacol-->5A molecular sieve-->4-Bromopyrazole-->4-Iodo-1-methyl-1H-pyrazole-->4-Bromo-1-methylpyrazole-->4-Chloro-1-methylpyrazole-->1-Methyl-1H-pyrazole-4-boronic acid-->2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->4-Pyrazoleboronic acid pinacol ester
Preparation Products	1-Methyl-1H-pyrazole-5-boronic acid pinacol ester-->7-bromo-2-(1-methyl-1H-pyrazol-4-yl)Quinoxaline-->1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

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