4-Pyridyl acetone

4-Pyridyl acetone Basic information

Description Preparation

Product Name:	4-Pyridyl acetone
Synonyms:	1-(4-Pyridyl)-2-propanone;4-Pyridinolacetone;(4-Pyridyl)acetone,98%;1-(4-Pyridinyl)-2-propanone CAS:;(4-PYRIDINEYL)-ACETONE;1-(4-Pyridyl)-2-acetone;Einecs 228-605-7;1-pyridin-4-ylacetone
CAS:	6304-16-1
MF:	C8H9NO
MW:	135.16
EINECS:	228-605-7
Product Categories:	Pyridines
Mol File:	6304-16-1.mol

4-Pyridyl acetone Chemical Properties

Melting point	13°C
Boiling point	143°C 20mm
density	1.046±0.06 g/cm3(Predicted)
refractive index	1.5225
Fp	143°C/20mm
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	4.90±0.10(Predicted)
form	Oil
color	Light Brown to Brown
Water Solubility	Slightly soluble in water.
BRN	110960
InChIKey	ILRVKOYYFFNXDB-UHFFFAOYSA-N
CAS DataBase Reference	6304-16-1(CAS DataBase Reference)

Safety Information

Risk Statements	36/37/38
Safety Statements	26-36/37/39-37
HS Code	29337900

MSDS Information

Provider	Language
ALFA	English

4-Pyridyl acetone Usage And Synthesis

Description	1-(4-pyridyl)acetone is a yellow liquid, which is a key intermediate for synthesizing cardiac drug Milrinone.
Preparation	4-Pyridyl acetone can be prepared by reacting with 4-picoline and phenyllithium and ethyl acetate.
Physical properties	4-pyridyl acetone is a Light yellow to yellow liquid.
Uses	(4-Pyridyl)acetone is a reactant in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.
Synthesis Reference(s)	Tetrahedron Letters, 25, p. 3297, 1984 DOI: 10.1016/S0040-4039(01)81368-X

4-Pyridyl acetone Preparation Products And Raw materials

Raw materials	Ethanol-->Ethyl acetate-->Tetrahydrofuran-->Acetic acid-->PETROLEUM ETHER-->Chloroform-->n-Butyllithium-->Diisopropylamine-->Hexamethylphosphoramide-->4-Methylpyridine-->Phenyllithium-->N-methoxy-N-methyl-2-(pyridin-4-yl)acetamide-->4-Pyridineacetic acid hydrochloride-->Propyl acetate-->Methyl acetate-->Acetyl chloride-->Methylmagnesium Bromide-->Pyridine
Preparation Products	Milrinone

Pyrazine Benzenesulfonyl chloride Trifluoromethanesulfonic acid RARECHEM AK HZ 0058 2-(9-ACRIDINYL)-1-PHENYLETHANONE 4-Pyridyl acetone 4-Pyridinyl[3-(trifluoromethyl)phenyl]-ethanedione 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE 2-(4-PYRIDYL)INDANE-1,3-DIONE 2-QUINOLIN-4-YL-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE Acetone 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE 1-(4-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE

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