N,N-Dimethylpiperidin-4-amine

N,N-Dimethylpiperidin-4-amine Basic information
Product Name:N,N-Dimethylpiperidin-4-amine
Synonyms:N,N-DIMETHYLPIPERIDIN-4-AMINE;AKOS BB-9178;4-(N,N-DIMETHYLAMINO)PIPERIDINE;4-DIMETHYLAMINO-PIPERIDINE;CHEMBRDG-BB 4018153;4-(Dimethylamino)piperidine,98%;N,N-Dimethyl-4-piperidinamine;N,N-Dimethylpiperidine-4-amine
CAS:50533-97-6
MF:C7H16N2
MW:128.22
EINECS:256-617-2
Product Categories:Amines and Anilines;Heterocycles;Piperidine
Mol File:50533-97-6.mol
N,N-Dimethylpiperidin-4-amine Structure
N,N-Dimethylpiperidin-4-amine Chemical Properties
Boiling point 187°C
density 1.09g/ml
Fp 187°C
refractive index 1.4760
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka10.10±0.10(Predicted)
form liquid
color Clear, colourless
BRN 1190
CAS DataBase Reference50533-97-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 10-34-22
Safety Statements 26-36/37/39-45
RIDADR 2734
Hazard Note Irritant
HazardClass 8
PackingGroup III
HS Code 2933399990
MSDS Information
N,N-Dimethylpiperidin-4-amine Usage And Synthesis
Uses4-(Dimethylamino)piperidine is having molecular features associated with polyamine modulation of N-methyl-D-aspartate receptors. It is utilized as a mechanism for reducing the effects of alcohol dependence.
Synthesis2.jpg
1-(tert-Butoxycarbonyl)-4-piperidone (998 mg, 4.75 mmol) in methanol (15 mL) was treated with dimethylamine hydrochloride (800 mg, 9.8 mmol) and sodium cyanoborohydride (270 mg, 4.3 mmol) at rt. After 4 days, concentrated HCl (10 mL) was added and volume of the reaction was reduced in vacuo. The resulting residue was dissolved in H2O (30 mL) and treated with a 2M NaOH solution to achieve a pH of 10. The aqueous solution was extracted with methylene chloride (3×20 mL) and the combined organics were dried over Na2SO4 and removed in vacuo. The resulting amine 106 (169 mg).
N,N-Dimethylpiperidin-4-amine Preparation Products And Raw materials
Raw materialsBenzoyl chloride-->Sodium cyanoborohydride-->Dimethylamine hydrochloride-->4,4-Piperidinediol hydrochloride-->MOLECULAR SIEVE
Preparation Products4-AMINO-1-METHYLPIPERIDINE
4-DIMETHYLAMINO-2,2,6,6-TETRAMETHYLPIPERIDINE N,N-DIMETHYLPIPERIDIN-3-AMINE N,N-Dimethylpiperidin-4-amine N-Boc-4-Dimethylaminopiperidine N-{2-amino-1-[4-(methylsulfanyl)phenyl]ethyl}-N,1-dimethylpiperidin-4-amine 4-(aminomethyl)-N-[(3-fluorophenyl)methyl]-N,1-dimethylpiperidin-4-amine 4-(DIMETHYLAMINO)-1,2,2,6,6-PENTAMETHYLPIPERIDINE N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride 4-(1-pyrrolidinyl)piperidine dihydrochloride 1-(2-chloropyrimidin-4-yl)-N,N-dimethylpiperidin-4-amine Fentanyl citrate 4-MALEIMIDO-TEMPO AMO 1618 N-(6-aminohexyl)-N,1-dimethylpiperidin-4-amine 1-(4-(AMINOMETHYL)PHENYL)-N,N-DIMETHYLPIPERIDIN-4-AMINE DIHYDROCHLORIDE 4-(dimethylammonio)piperidinium dichloride N-(2-amino-3-methylbutyl)-N,1-dimethylpiperidin-4-amine 1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE

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