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| N,N-Dimethylpiperidin-4-amine Basic information |
| N,N-Dimethylpiperidin-4-amine Chemical Properties |
Boiling point | 187°C | density | 1.09g/ml | Fp | 187°C | refractive index | 1.4760 | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | pka | 10.10±0.10(Predicted) | form | liquid | color | Clear, colourless | BRN | 1190 | CAS DataBase Reference | 50533-97-6(CAS DataBase Reference) |
Hazard Codes | Xi,Xn | Risk Statements | 10-34-22 | Safety Statements | 26-36/37/39-45 | RIDADR | 2734 | Hazard Note | Irritant | HazardClass | 8 | PackingGroup | III | HS Code | 2933399990 |
| N,N-Dimethylpiperidin-4-amine Usage And Synthesis |
Uses | 4-(Dimethylamino)piperidine is having molecular features associated with polyamine modulation of N-methyl-D-aspartate receptors. It is utilized as a mechanism for reducing the effects of alcohol dependence. | Synthesis | 1-(tert-Butoxycarbonyl)-4-piperidone (998 mg, 4.75 mmol) in methanol (15 mL) was treated with dimethylamine hydrochloride (800 mg, 9.8 mmol) and sodium cyanoborohydride (270 mg, 4.3 mmol) at rt. After 4 days, concentrated HCl (10 mL) was added and volume of the reaction was reduced in vacuo. The resulting residue was dissolved in H2O (30 mL) and treated with a 2M NaOH solution to achieve a pH of 10. The aqueous solution was extracted with methylene chloride (3×20 mL) and the combined organics were dried over Na2SO4 and removed in vacuo. The resulting amine 106 (169 mg). |
| N,N-Dimethylpiperidin-4-amine Preparation Products And Raw materials |
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