2-Hydrazinopyridine

2-Hydrazinopyridine Basic information

Product Name:	2-Hydrazinopyridine
Synonyms:	2-HYDRAZINOPYRIDINE PYRIDIN-2-YL-HYDRAZINE;Hydrazinopyridine;2-hydrazinylpyridine;2-HYDRAZINOPYRIDINE 97+%;2-PYRIDYLHYDRAZINE;2-HYDRAZINOPYRIDINE;PYRIDIN-2-YL-HYDRAZINE;(2E)-2(1H)-Pyridinone hydrazone
CAS:	4930-98-7
MF:	C5H7N3
MW:	109.13
EINECS:	225-566-8
Product Categories:	Heterocycle-Pyridine series;Heterocyclic Compounds;Pyridines, Pyrimidines, Purines and Pteredines
Mol File:	4930-98-7.mol

2-Hydrazinopyridine Chemical Properties

Melting point	41-44 °C (lit.)
Boiling point	90-92 °C/1 mmHg (lit.)
density	1.1118 (rough estimate)
refractive index	1.5340 (estimate)
Fp	>230 °F
storage temp.	2-8°C
solubility	soluble in Methanol
pka	9.72±0.70(Predicted)
form	crystalline
color	deep red
BRN	109984
InChIKey	NWELCUKYUCBVKK-UHFFFAOYSA-N
CAS DataBase Reference	4930-98-7(CAS DataBase Reference)
NIST Chemistry Reference	2-Hydrazinopyridine(4930-98-7)
EPA Substance Registry System	2-Hydrazinopyridine (4930-98-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	3-10-34
HS Code	29339900

MSDS Information

Provider	Language
2-Pyridylhydrazine	English
SigmaAldrich	English

2-Hydrazinopyridine Usage And Synthesis

Chemical Properties	White to light beige low melting solid
Synthesis Reference(s)	Journal of Medicinal Chemistry, 28, p. 1394, 1985 DOI: 10.1021/jm00148a004
Purification Methods	Purify it by distillation under a vacuum and by recrystallisation from Et2O/hexane. [Kauffmann et al. Justus Liebigs Ann Chem 656 103 1962, Potts & Burton J Org Chem 31 251 1966.] The mono-hydrochloride has m 183o(dec) from aqueous HCl, and the di-hydrochloride has m 214-215o. [Beilstein 22 II 487, 22 III/IV 7025, 22/14 V 486.]

2-Hydrazinopyridine Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Dichloromethane-->Hydrazinium hydroxide solution-->4-Bromobenzaldehyde-->2-Bromopyridine-->(E)-2-Pyridinecarbaldehyde (2-pyridyl)hydrazone-->2-Pyridinecarboxaldehyde, 2-phenylhydrazone, [C(E)]--->(Z)-2-pyridinecarbaldehyde (2-pyridyl)hydrazone-->2-Chloropyridine-->N-Nitro-2-pyridinamine-->PYRIDINE-2-SULFONIC ACID-->Hydrazine hydrate-->Phenylhydrazine
Preparation Products	5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE-->1-pyridin-2-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid-->ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE

Sulfasalazine 1-(6-METHYL-4-(TRIFLUOROMETHYL)PYRID-2-YL)-1-METHYLHYDRAZINE 2-Hydrazinopyridine 1-(2,3-Dimethylphenyl)piperazine 2-Chloro-3-cyanopyridine 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE N-[5-(TRIFLUOROMETHYL)PYRID-2-YL]-N-METHYLHYDRAZINE N-[3-(TRIFLUOROMETHYL)PYRID-2-YL]-N-METHYLHYDRAZINE 4-Methylpyridine 3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-Aminopyridine 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]-1-METHYLHYDRAZINE Carbobenzoxyhydrazide Chromium picolinate Pyridine N-Nitro-2-pyridinamine tert-Butyl carbazate

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