ChemicalBook Product Catalog Chemical Reagents Organic reagents fatty acid 2-Hydroxyisobutyric acid

2-Hydroxyisobutyric acid

2-Hydroxyisobutyric acid Basic information
Product Name:2-Hydroxyisobutyric acid
Synonyms:Propanoic acid, 2-methyl-2-hydroxy-;A-HYDROXY-ISO-BUTYRIC ACID;2-MethyllaCLic Acid;alpha-Hydroxyisobutyric acid 98%;2-Hydroxyisobutyric acid for synthesis;RARECHEM AL BO 0199;alpha-Hydroxyisobutanoic acid;Hydroxydimethylacetic acid
CAS:594-61-6
MF:C4H8O3
MW:104.1
EINECS:209-848-8
Product Categories:Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;FINE Chemical & INTERMEDIATES;Organic acids;Building Blocks;C1 to C5;Carbonyl Compounds;bc0001
Mol File:594-61-6.mol
2-Hydroxyisobutyric acid Structure
2-Hydroxyisobutyric acid Chemical Properties
Melting point 76-80 °C(lit.)
Boiling point 84 °C1.5 mm Hg(lit.)
density 11412
refractive index 1.4761 (estimate)
Fp 114°C/12mm
storage temp. Sealed in dry,Room Temperature
solubility water: soluble10%, clear to very slightly hazy, colorless
form Solid
pkapK1:3.717 (25°C,μ=0.1)
color White to Off-White
Water Solubility Soluble in water, ether, alcohol, methanol and hot benzene.
BRN 1744739
LogP-0.360
CAS DataBase Reference594-61-6(CAS DataBase Reference)
NIST Chemistry ReferencePropanoic acid, 2-hydroxy-2-methyl-(594-61-6)
EPA Substance Registry SystemPropanoic acid, 2-hydroxy-2-methyl- (594-61-6)
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41-36/37/38
Safety Statements 26-39-25-36
WGK Germany 3
Hazard Note Irritant
TSCA Yes
HS Code 29181980
MSDS Information
ProviderLanguage
2-Methyllactic acid English
SigmaAldrich English
ACROS English
ALFA English
2-Hydroxyisobutyric acid Usage And Synthesis
Chemical Propertieswhite to off-white needle-like crystals or
Usesα-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.
Uses2-Hydroxyisobutyric acid is used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.
Uses2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.
DefinitionChEBI: A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether.
Synthesis Reference(s)The Journal of Organic Chemistry, 23, p. 1488, 1958 DOI: 10.1021/jo01104a022
General Descriptionα-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy.
(R)-3,3,3-TRIFLUORO-2-HYDROXYISOBUTYRIC ACID Methyl 2-bromo-2-methylpropionate NEOPENTYL GLYCOL MONO(HYDROXYPIVALATE) 2-Hydroxyisobutyric Acid Propenyl Ester 2,2-Bis(hydroxymethyl)propionic acid Benzilic acid Ethyl 2-(Chlorosulfonyl)acetate Hydroxy silicone oil Ascoric Acid N-(2-HYDROXYETHYL)-ETHYLENEDIAMINE-N,N',N'-TRIACETIC ACID 2-HYDROXYISOBUTYRIC ACID Sucrose acetate isobutyrate Dimethyl 2,2'-azobis(2-methylpropionate) 9-HYDROXYFLUORENE-9-CARBOXYLIC ACID (R)-(-)-2-HYDROXY-4-PHENYLBUTYRIC ACID AGARIC ACID 2,3-Dibromopropionic acid CHLOROPHOSPHONAZO III 2-ETHYL-2-HYDROXYBUTYRIC ACID
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