5-alpha-Dihydroprogesterone

5-alpha-Dihydroprogesterone Basic information
Description In vitro
Product Name:5-alpha-Dihydroprogesterone
Synonyms:5-Alpha-Dihydro Progesterone-d8;Pregnane-3,20-dlone;ALLOPREGNANE-3,20-DIONE;ALLOPREGNAN-3,20-DIONE;ALLOPREGNANDIONE;(5S,8R,9S,10S,13S,14S,17S)-17-ACETYL-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE;5 A-PREGNANE-3 20-DIONE;5A-PREGNAN-3,20-DIONE
CAS:566-65-4
MF:C21H32O2
MW:316.48
EINECS:209-297-3
Product Categories:Steroids;566-65-4
Mol File:566-65-4.mol
5-alpha-Dihydroprogesterone Structure
5-alpha-Dihydroprogesterone Chemical Properties
Melting point 200 °C
Boiling point 429.2±38.0 °C(Predicted)
density 1.048±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color White to Off-White
InChIInChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14?,16-,17+,18-,19-,20-,21+/m0/s1
InChIKeyXMRPGKVKISIQBV-CVHNGYJVSA-N
SMILESC1(=O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)C)CC3)CC2
CAS DataBase Reference566-65-4(CAS DataBase Reference)
NIST Chemistry Reference3,20-Allopregnanedione(566-65-4)
Safety Information
WGK Germany 3
RTECS TU4157150
HS Code 2937.29.9095
MSDS Information
ProviderLanguage
5-alpha-Dihydroprogesterone English
SigmaAldrich English
5-alpha-Dihydroprogesterone Usage And Synthesis
Description5α-Dihydroprogesterone (5α-DHP) is an endogenous progestogen and neurosteroid that is synthesized from progesterone.It is also an intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone.
In vitro5a-Pregnane-3,20-dione decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerizes F-actin in MCF-7 breast cancer cells.
Uses(5α)-Pregnane-3,20-dione exerts neuroprotective effects in chronic autoimmune encephalomyelitis (EAE). The neuroactivity of the steroid acts as a therapeutic agent for multiple sclerosis.
DefinitionChEBI: 5alpha-pregnane-3,20-dione is a C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone. It has a role as a human metabolite and a progestogen. It is a 20-oxo steroid, a C21-steroid hormone and a 3-oxo-5alpha-steroid. It is functionally related to a progesterone. It derives from a hydride of a 5alpha-pregnane.
Biochem/physiol Actions(5α)-Pregnane-3,20-dione is a high-level metabolite of progesterone in breast cancer tissue (but not normal breast tissue); promotes cell proliferation and detachment. Receptors appear only on the cell surface of MCF-7 breast cancer cells, not on nuclei where most other steroid receptors are located.
5-alpha-Dihydroprogesterone Preparation Products And Raw materials
Raw materialsPREGNANEDIONE-->Progesterone
Preparation ProductsPregnan-20-one, 3-hydroxy-3-methyl-, (3β,5α)--->GANAXOLONE-->Pregnan-20-one, (5alpha)-
5-alpha-Dihydroprogesterone 5-ALPHA-DIHYDROCORTICOSTERONE Dehydroepiandrosterone Pregnenolone 5A-PREGNAN-21-OL-3-20-DIONE CRYSTALLINE 5-ALPHA-PREGNAN-11-ALPHA, 21-DIOL-3,20-DIONE Gestrinone Gestodene Progesterone 17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE 5ALPHA-DIHYDROALDOSTERONE 5-ALPHA-PREGNAN-11-ALPHA, 21-DIOL-3,20-DIONE 11-ACETATE 16-Dehydroprogesterone Ecdysone Medroxyprogesterone Acetate 5-ALPHA-PREGNAN-4-ALPHA-BROMO-17,21-DIOL-3,11,20-TRIONE 21-ACETATE 5-ALPHA-DIHYDROCORTISONE Diethylstilbestrol

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