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| | PROTOVERATRINE B Basic information |
| Product Name: | PROTOVERATRINE B | | Synonyms: | [3beta(2R,3R),4alpha,6alpha,7alpha,15alpha(R),16beta]-4,9-epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2,3-dihydroxy-2-methylbutyrate) 15-(2-methylbutyrate);PROTOVERATRINE B (RG);PROTOVERATRINE B;NEOPROTOVERATRINE;4-beta,6-alpha,7-alpha,14,15-alpha-16-beta,20-octol,4,9-epoxy-cevane-3-bet;4α,9-Epoxycevane-3β,4β,6α,7α,14,15α,16β,20-octol 6,7-diacetate 3-[(2R,3R)-2,3-dihydroxy-2-methylbutanoate]15-[(R)-2-methylbutanoate];PROTOVERATRINE A (RG)(CALL);6,7-diacetate3-(threo-(+)-2,3-dihydroxy-2-methylbutyrate)15-((-)-2-methylbut | | CAS: | 124-97-0 | | MF: | C41H63NO15 | | MW: | 809.94 | | EINECS: | 204-719-2 | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 124-97-0.mol |  |
| | PROTOVERATRINE B Chemical Properties |
| Melting point | 268-270°C | | alpha | D25 -37° (pyridine); D25 -3.5° (chloroform) | | Boiling point | 755.18°C (rough estimate) | | density | 1.1826 (rough estimate) | | refractive index | 1.6220 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 10.73±0.70(Predicted) |
| Safety Statements | 22-24/25 | | RIDADR | 1544 | | WGK Germany | 3 | | RTECS | FL5750000 | | HazardClass | 6.1(a) | | PackingGroup | II | | Toxicity | LD50 s.c. in male mice: 0.21 mg/kg (Tanaka) |
| | PROTOVERATRINE B Usage And Synthesis |
| Description | Also present in Veratrum album, this closely allied alkaloid may be separated
from the preceding base by chromatography. It also yields colourless crystals
from EtOH and is laevorotatory with [α]29D&o - 39.8° (pyridine) or - 3.5° (CHCI3).
In this case, alkaline hydrolysis gives protoverine, two moles of acetic acid, one
mole of (-)-2-methylbutyric acid and one mole of 2: 3-dihydroxy-2-
methylbutyric acid. It may be distinguished from protoveratrine A by giving a
green colour with H2S04. It also forms a complex with maleic acid having m.p.
222.2°C; [α]29D&o - 27.3°. | | References | Stoll, Seebeck., Helv. Chim. Acta., 36,718 (1953) |
| | PROTOVERATRINE B Preparation Products And Raw materials |
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