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| | Hydrocortisone sodium succinate Basic information |
| Product Name: | Hydrocortisone sodium succinate | | Synonyms: | 11b,17a,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt;11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM-POTASSIUM SALT;11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;HYDROCORTISONE HEMISUCCINATE SODIUM SALT;HYDROCORTISONE-HYDROGEN SUCCINATE SODIUM SALT;HYDROCORTISONE SODIUM SUCCINATE;HYDROCORTISONE 21-HEMISUCCINATE SODIUM;HYDROCORTISONE 21-HEMISUCCINATE SODIUM SALT | | CAS: | 125-04-2 | | MF: | C25H33O8.Na | | MW: | 484.52 | | EINECS: | 204-725-5 | | Product Categories: | Steroid and Hormone;125-04-2 | | Mol File: | 125-04-2.mol |  |
| | Hydrocortisone sodium succinate Chemical Properties |
| Melting point | 169.0-171.2° | | storage temp. | −20°C | | solubility | H2O: 50 mg/mL | | form | powder | | color | White to Off-White | | InChIKey | HHZQLQREDATOBM-CODXZCKSSA-M | | CAS DataBase Reference | 125-04-2(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | GM9015000 |
| | Hydrocortisone sodium succinate Usage And Synthesis |
| Uses | Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. | | Uses | Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.
| | Uses | Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells. | | Definition | ChEBI: Hydrocortisone Sodium Succinate is an organic molecular entity. | | Brand name | A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef
(Pharmacia & Upjohn). | | General Description | Hydrocortisone for use in epithelial and endothelial adherent cell culture applications. | | Drug interactions | Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration of hydrocortisone possibly
increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines. | | Metabolism | Hydrocortisone is metabolised in the liver and most
body tissues to hydrogenated and degraded forms such as
tetrahydrocortisone and tetrahydrocortisol.
These are excreted in the urine, mainly conjugated as
glucuronides, with a very small proportion of unchanged
hydrocortisone. |
| | Hydrocortisone sodium succinate Preparation Products And Raw materials |
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