Acetyl ketene

Acetyl ketene Basic information

Product Name:	Acetyl ketene
Synonyms:	3-buteno-beta-lactone;3-Butenoic acid, 3-hydroxy-, beta-lactone;4-methylene-2-oxetanon;diketene,inhibited;Ethenone, dimer;ethenone,dimer;Vinylaceto-beta-lactone;Vinylaceto-lactone
CAS:	674-82-8
MF:	C4H4O2
MW:	84.07
EINECS:	211-617-1
Product Categories:	Aromatic amine products;Pharmaceutical Intermediates
Mol File:	674-82-8.mol

Acetyl ketene Chemical Properties

Melting point	-7.5°C
Boiling point	69-70 °C100 mm Hg(lit.)
density	1.09 g/mL at 25 °C(lit.)
vapor density	2.9 (vs air)
vapor pressure	7.9 mm Hg ( 20 °C)
refractive index	n20/D 1.439(lit.)
Fp	95 °F
storage temp.	2-8°C
CAS DataBase Reference	674-82-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Oxetanone, 4-methylene-(674-82-8)
EPA Substance Registry System	Diketene (674-82-8)

Safety Information

Hazard Codes	Xn
Risk Statements	10-20-40-36/37/38
Safety Statements	3-36/37-33-24/25-23-16-26
RIDADR	UN 2929 6.1/PG 2
WGK Germany	2
RTECS	RQ8225000
F	19-21-27
HazardClass	6.1(a)
PackingGroup	I
Hazardous Substances Data	674-82-8(Hazardous Substances Data)
IDLA	7.6 ppm

MSDS Information

Provider	Language
Diketene	English
SigmaAldrich	English

Acetyl ketene Usage And Synthesis

Uses	Diketene is used as a reactant in the manufacture of paper and control of its sizing. In addition its used in the preparation of potent and selective inhibitor of histone methyltransferase EZH2 in the treatment of B-Cell lymphomas.
General Description	A colorless liquid with a disagreeable odor. Slightly less dense than water. Flash point 90°F. Irritates skin and eyes. Used to make paints and pharmaceuticals.
Air & Water Reactions	Highly flammable. Slightly soluble in water.
Reactivity Profile	DIKETENE is a very reactive dimer, Acetyl ketene may undergo a spontaneous decomposition followed by explosion or ignition [Vervalin, 1973, p.86]. In the presence of bases, amines, mineral acids or Lewis acids a violent polymerization will occur, accompanied by gas evolution [Zdenek, F. et al., Czech Pat. 156 584, 1975].
Health Hazard	TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard	HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. May polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Acetyl ketene Preparation Products And Raw materials

Raw materials

Acetic acid-->Acetone-->Polyethylene-->Butyl acetate-->ketene-->Triethyl phosphate-->Polymerization inhibitor

Preparation Products

Acetic anhydride-->Ethyl acetoacetate-->Chloroacetyl chloride-->5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one-->Methyl acetoacetate-->Acetoacetanilide-->Sorbic acid-->Pigment Red 122-->Quizalofop-p-ethyl-->Dehydroacetic acid-->Butyric anhydride-->2-Acetylbutyrolactone-->Acesulfame-->Imazethapyr-->Ethyl 4-chloroacetoacetate-->Acesulfame potassium-->o-Acetoacetaniside-->Olaquindox-->tert-Butyl acetoacetate-->N,N-Diethylacetoacetamide-->Manidipine-->Amitriptyline hydrochloride-->Seedavay(Uniroyal)-->N-Methylacetoacetamide-->Isobutyl acetoacetate-->2'-Chloroacetoacetanilide-->PHOSPHAMIDON-->Acetoacetamide-->2'-Methylacetoacetanilide-->ACETOACETIC ACID N-BUTYL ESTER-->22(S),23(S)-Homobrassinolide-->2,6-HEPTANEDIONE-->5-CHLORO-6 B,19-EPOXY-5A -ANDROTANE-3,17-DIONE-->N-Acetyl-N-(4-chloro-2-nitrophenyl)acetamide-->Dichlorosulfophenyl-3-methylpyrazolone-->FEMA 2510-->N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide)-->4'-Methoxyacetoacetanilide

1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 1H-Pyrazole, 5-methoxy-3-methyl-1-phenyl- Edaravone Impurity 14 Edaravone Impurity 26 Edaravone Impurity 5 Edaravone Impurity 8 ethyl 3-acetoxy-2-butenoate Edaravone Impurity 15 Edaravone Impurity 19 1H-Pyrazole,3-ethoxy-5-methyl-1-phenyl-(9CI) Edaravone Impurity 6 NSC4751 Edaravone 5-Oxo-1-phenyl-2-pyrazolin-3-carboxylic acid Polyvinylpyrrolidone cross-linked VINYL FORMATE ACETYLACETONATE KETENE

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