Furfurylamine

Furfurylamine Basic information
Product Name:Furfurylamine
Synonyms:AKOS BBS-00003604;1-(2-FURYL)METHYLAMINE;2-AMINOMETHYLFURAN;2-FURANMETHYLAMINE;2-FURFURYLAMINE;1-(2-furyl)-methylamin;alpha-Furfurylamine;Methylamine, 1-(2-furyl)-
CAS:617-89-0
MF:C5H7NO
MW:97.12
EINECS:210-536-9
Product Categories:pharmaceutical;Building Blocks;C4 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Heterocycles;Miscellaneous Reagents;Pharmaceutical Intermediates;Furans;Anilines, Aromatic Amines and Nitro Compounds;Furan&Benzofuran;Amines
Mol File:617-89-0.mol
Furfurylamine Structure
Furfurylamine Chemical Properties
Melting point −70 °C(lit.)
Boiling point 145-146 °C(lit.)
density 1.099 g/mL at 25 °C(lit.)
vapor density 3.35 (vs air)
vapor pressure 4 mm Hg ( 20 °C)
refractive index n20/D 1.490(lit.)
Fp 116 °F
storage temp. Store below +30°C.
solubility Chloroform, Ethyl Acetate (Slightly)
form Liquid
pka9.12±0.29(Predicted)
color Clear colorless to yellow-brown
PH11.6 (100g/l, H2O, 20℃)
Odorstrong fishy ammonia-like odor
explosive limit1.8%(V)
Water Solubility soluble
Sensitive Air Sensitive
BRN 1614
Stability:Volatile
LogP0.37
CAS DataBase Reference617-89-0(CAS DataBase Reference)
NIST Chemistry Reference2-Furanmethanamine(617-89-0)
EPA Substance Registry SystemFurfurylamine (617-89-0)
Safety Information
Hazard Codes C,F,Xi
Risk Statements 10-21/22-34-20/21/22
Safety Statements 26-36/37/39-45-23-16
RIDADR UN 2526 3/PG 3
WGK Germany 3
RTECS LU9275000
Autoignition Temperature350 °C DIN 51794
Hazard Note Harmful/Corrosive/Flammable
TSCA Yes
HazardClass 3
PackingGroup III
HS Code 29321900
ToxicityLD50 orally in Rabbit: 200 - 2000 mg/kg LD50 dermal Rat 100 mg/kg
MSDS Information
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Furfurylamine English
SigmaAldrich English
ACROS English
ALFA English
Furfurylamine Usage And Synthesis
Chemical PropertiesFurfurylamine is a colorless to light yellow aromatic amine in liquid form with an ammonia odor. Miscible with water, soluble in ethanol, ether. Deteriorates in air by absorbing carbon dioxide. Derived from furfural based on corn cobs, this green chemistry has proven useful in engine cleaners, and as an intermediate for pharmaceutical, industrial and agricultural chemicals.
UsesFurfurylamine is used as a water miscible solvent and as an intermediate in manufacturing pharmaceuticals like diuretics, antihypertensive, and antiseptic agents.
Furfurylamine also has use in the synthesis of Barmastine.
2-Furfurylamine is used in the synthesis of 2-Amino-N-(2-furylmethyl)propanamide, as a novel alanylglycine equivalent synthesized by bacilysin synthetase.
PreparationSynthesis of furfurylamine by Zn/HCl system: To a solution of furfuryloxime (2g, 18mmol) in hydrochloric acid (6.0M, 24ml) was added drop-wise zinc dust (4.71g, 72mmol), and the resultant solution was stirred at room temperature for 2 h. To the resulting slurry was added drop-wise a solution of ammonia (30%, 5.1 mL) and sodium hydroxide (6M, 24mL), the mixture was heated to 60° and stirred for 15mn. After, the resultant solution was cooled and filtered. Then, the mother liquid was extracted with cyclohexane, dried over anhydrous sodium sulfate and filtered. The solvent was removed under vacuum to afford the furfurylamine as a yellow liquid without further purification in 96% of yield (1.68g). The purity determined by NMR was found to be superior to 95%.
SIMPLE, NOVEL SYNTHESIS OF FURFURYLAMINE FROM FURFURAL BY ONE-POT REDUCTIVE AMINATION IN WATER USING ZINC METAL
General DescriptionFurfurylamine appears as a colorless liquid. About the same density as water. Used as a corrosion inhibitor and to make soldering flux.
Air & Water ReactionsHighly flammable. Soluble in water.
Reactivity ProfileAmines, such as Furfurylamine, are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
HazardFlammable, moderate fire risk.
Health HazardMay cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and ExplosibilityFlammable
Safety ProfilePoison by intraperitoneal route. A skin,eye, and mucous membrane irritant. A dangerous fire hazard when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, drp chemical. When heated to decomposition it emits toxic fumes of NOx. See also MINES.
Furfurylamine Preparation Products And Raw materials
Preparation ProductsFurosemide-->FUBERIDAZOLE-->N-(2-FURYLMETHYL)-N-(THIEN-2-YLMETHYL)AMINE-->N-FURAN-2-YLMETHYL-SUCCINAMIC ACID-->6-Chloro-4-(furfurylaMino)pyriMidine, 96%-->4-cyano-N-(furan-2-ylmethyl)benzene-1-sulfonamide-->2-[(2-furylmethyl)amino]nicotinonitrile-->4-(4-CHLORO-6-[(FURAN-2-YLMETHYL)-AMINO]-[1,3,5]TRIAZIN-2-YLAMINO)-PHENOL-->2-CYANO-3-FURANE-2-YL-ACRYLIC ACID ETHYL ESTER-->Acetamide,N-(2-furanylmethyl)-
4-CHLORO-N-(2-FURYLMETHYL)BENZENESULFONAMIDE N,N-DIMETHYL-5-METHYLFURFURYLAMINE TIMTEC-BB SBB006349 AMINO-FURAN-2-YL-ACETIC ACID 4-[(FURAN-2-YLMETHYL)-CARBAMOYL]-BUTYRIC ACID SALOR-INT L450200-1EA N-(4-bromophenyl)-2-furamide 1,3-DIFURFURYL-2-THIOUREA FURAN-2-CARBOXYLIC ACID (4-HYDROXY-PHENYL)-AMIDE AURORA 6585 N-(2-FUROYL)GLYCINE TIMTEC-BB SBB005348 N-(2-FURYLMETHYL)MALEIMIDE trimethylamine oxide 3-FURAN-2-YLMETHYL-2-THIOXO-THIAZOLIDIN-4-ONE 5-bromo-2-furamide HYDROFURAMIDE 2-FURFURYL ISOTHIOCYANATE

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