ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluorotoluene series 2,4,5-TRIFLUOROBENZYL CHLORIDE

2,4,5-TRIFLUOROBENZYL CHLORIDE

2,4,5-TRIFLUOROBENZYL CHLORIDE Basic information
Product Name:2,4,5-TRIFLUOROBENZYL CHLORIDE
Synonyms:2,4,5-TRIFLUOROBENZYL CHLORIDE;2,4,5-TRIFLUOROBENZYL CHORIDE;Benzene, 1-(chloromethyl)-2,4,5-trifluoro- (9CI);1-(Chloromethyl)-2,4,5-trifluorobenzene, alpha-Chloro-2,4,5-trifluorotoluene;Sitagliptin Impurity 70;Benzene, 1-(chloromethyl)-2,4,5-trifluoro-;alpha-Chloro-2,4,5-trifluorotoluene
CAS:243139-71-1
MF:C7H4ClF3
MW:180.55
EINECS:
Product Categories:Fluorine series;HALOMETYL;Miscellaneous
Mol File:243139-71-1.mol
2,4,5-TRIFLUOROBENZYL CHLORIDE Structure
2,4,5-TRIFLUOROBENZYL CHLORIDE Chemical Properties
Boiling point 175℃
density 1,689 g/cm3
refractive index 1.5050
Fp 65°C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form clear liquid
color Colorless to Almost colorless
InChIInChI=1S/C7H4ClF3/c8-3-4-1-6(10)7(11)2-5(4)9/h1-2H,3H2
InChIKeyJMXPOOVDUVHJRO-UHFFFAOYSA-N
SMILESC1(CCl)=CC(F)=C(F)C=C1F
CAS DataBase Reference243139-71-1(CAS DataBase Reference)
Safety Information
Hazard Codes C,Xn
Risk Statements 34-36/37/38-20/21/22
Safety Statements 26-36/37/39-36
RIDADR 3265
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 2903998090
MSDS Information
ProviderLanguage
ALFA English
2,4,5-TRIFLUOROBENZYL CHLORIDE Usage And Synthesis
Chemical PropertiesColorless to Almost colorless clear liquid.
Uses2,4,5-Trifluorobenzyl chloride is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that decreases in glucagon to improve control of blood sugar used for the treatment of type 1 diabetes, 79% of the dose excreted in the urine.
Uses2,4,5-Trifluorobenzyl chloride is a useful research chemical.
SynthesisOn the four-neck flask, install a stirrer, a thermometer, a chlorine gas pipe and a reflux condenser. The reflux condenser is connected to the HCl absorption system, and a light source is installed near the flask.Add 146.0g 2,4,5-trifluorotoluene and 3.0g azobisisobutyronitrile into the reaction flask, stir and heat, and when the temperature rises to 110°C, add dry chlorine gas, and Using GC tracking, after about 3h of chlorine gas, stop the halogenating agent chlorine gas, cool the reactant, wash it with water to neutrality, dry and distill under reduced pressure to obtain 2,4,5-trifluorobenzyl chloride.
2,4,5-TRIFLUOROBENZYL CHLORIDE Preparation Products And Raw materials
Preparation Products2,4,5-Trifluorobenzyl bromide
Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Impurity 34 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate 3-HYDROXY-2,4,5-TRIFLUOROBENZOYL CHLORIDE 5-NITRO-2,3,4,5-TETRAFLUORO BENZOYL CHLORIDE (TRICHLOROMETHYL)PENTAFLUOROBENZENE Pentafluorobenzyl chloride 3-BROMO-2,4,5,6-TETRAFLUOROBENZYLCHLORIDE 3-CHLORO-2,4,5-TRIFLUOROBENZOYL CHLORIDE 3,4,5-TRIFLUOROBENZYL CHLORIDE 3,4,5,6-Tetrachloro-N-methylphthalimide 2-BROMO-3,4,5,6-TETRAFLUOROBENZYLCHLORIDE 2,4,5-TRIFLUORO-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE 2,4,6-TRIFLUOROBENZYL CHLORIDE 3-Chloro-2,4,5,6-tetrafluorobenzylchloride
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