3-Maleimidobenzoic acid N-hydroxysuccinimide ester

3-Maleimidobenzoic acid N-hydroxysuccinimide ester Basic information
Product Name:3-Maleimidobenzoic acid N-hydroxysuccinimide ester
Synonyms:3-MALEIMIDOBENZOIC ACID N-HYDROXYSUCCINIMIDE ESTER;3-MALEIMIDOBENZOIC ACID N-SUCCINIMIDYL ESTER;3-(2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-yl)benzoic acid 2,5-dioxopyrrolidine-1-yl ester;3-(2,5-Dioxo-3-pyrroline-1-yl)benzoic acid succinimidyl ester;3-(Maleimide-N-yl)benzoic acid succinimidyl ester;3-[(2,5-Dioxo-2,5-dihydro-1H-pyrrole)-1-yl]benzoic acid 2,5-dioxo-1-pyrrolidinyl ester;Succinimidylmaleimidobenzoate;m-Maleimidoacetoxy N-Hydroxysuccinimide Ester
CAS:58626-38-3
MF:C15H10N2O6
MW:314.25
EINECS:261-368-8
Product Categories:Nitric Oxide Reagents;N-Substituted Maleimides;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Cross Linking Reagents;Maleimide Derivatives;Cross Linking Reagents,Maleimide Derivatives;heteroXlink;MTS & Sulfhydryl Active Reagents;Heterobifunctional Crosslinker
Mol File:58626-38-3.mol
3-Maleimidobenzoic acid N-hydroxysuccinimide ester Structure
3-Maleimidobenzoic acid N-hydroxysuccinimide ester Chemical Properties
Melting point 175-177 °C(lit.)
Boiling point 524.5±52.0 °C(Predicted)
density 1.59±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility ethyl acetate or DMF: ≤20 mg/mL may require addition of solvent to coupling buffer to at least 5% to maintain solubility
form crystalline
pka-2.63±0.20(Predicted)
color White to Almost white
Sensitive Moisture & Light Sensitive
BRN 1505254
InChIKeyLLXVXPPXELIDGQ-UHFFFAOYSA-N
CAS DataBase Reference58626-38-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
10-21
HS Code 29280000
MSDS Information
ProviderLanguage
SigmaAldrich English
3-Maleimidobenzoic acid N-hydroxysuccinimide ester Usage And Synthesis
DescriptionMBS is a heterobifunction crosslinker that contains a maleimide group which is reactive towards sulfhydryls and an NHS ester, useful for targeting amine groups.
Chemical PropertiesCrystalline
Uses3-Maleimidobenzoic acid N-hydroxysuccinimide ester is a heterobifunctional coupling reagent useful for forming enzyme immunoconjugates. The reactive groups are the NHS ester and maeimide.
UsesN-Succinimidyl 3-maleimidobenzoate is useful for forming enzyme immunoconjugates. It has a 9.9 Angstrom spacer arm. Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates
Biochem/physiol Actions3-Maleimidobenzoic acid N-hydroxysuccinimide is used as a fixative for the preservation of pollen tube F-actin distribution. It imposes less damage when used on pollen tubes.
3-Maleimidobenzoic acid N-hydroxysuccinimide ester Preparation Products And Raw materials
3-Maleimidobenzoic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide O-Phthalimide Maleimido-3,5-disuccinimidyl isophthalate Ethyl 2-(Chlorosulfonyl)acetate Bismaleimide Tris(trimethylsilyl)phosphate 3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-BENZOIC ACID N-SUCCINIMIDYL-3,5-DIMALEIMIDOPHENYL BENZOATE Succinimide DIALIFOS Maleimide N-Chlorosuccinimide BUTYL OLEATE Methyl acrylate M-MALEIMIDOBENZOYL-N-HYDROXYSULFOSUCCINIMIDE ESTER

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