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| | 2-Acetamidophenol Basic information |
| | 2-Acetamidophenol Chemical Properties |
| Melting point | 205-210 °C(lit.) | | Boiling point | 273.17°C (rough estimate) | | density | 1.2023 (rough estimate) | | refractive index | 1.5810 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 9.35±0.35(Predicted) | | form | Powder | | color | Off-white to beige to brown | | BRN | 607592 | | Stability: | Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides. | | CAS DataBase Reference | 614-80-2(CAS DataBase Reference) | | NIST Chemistry Reference | Acetamide, N-(2-hydroxyphenyl)-(614-80-2) | | EPA Substance Registry System | 2'-Hydroxyacetanilide (614-80-2) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/38-22-36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | AE4025000 | | F | 1-8 | | TSCA | Yes | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29242995 |
| | 2-Acetamidophenol Usage And Synthesis |
| Chemical Properties | white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water. | | Uses | An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis. | | Definition | ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides. | | Preparation | Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol. | | General Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | Purification Methods | Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.] |
| | 2-Acetamidophenol Preparation Products And Raw materials |
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