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| | 7,8-DIHYDRO-L-BIOPTERIN Basic information |
| Product Name: | 7,8-DIHYDRO-L-BIOPTERIN | | Synonyms: | 7,8-dihydrobiopterin;7,8-DIHYDRO-L-BIOPTERIN;2-AMINO-6-(1R,2S-DIHYDROXYPROPYL)-7,8-DIHYDRO-4(1H)-PTERIDINONE;1-(2-Amino-4-hydroxy-7,8-dihydropteridin-7-yl)propane-1,2-diol;BH2;DIHYDROBIOPTERIN;2-Amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-3H-pteridin-4-one;2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone | | CAS: | 6779-87-9 | | MF: | C9H13N5O3 | | MW: | 239.23 | | EINECS: | | | Product Categories: | Amines;Bases & Related Reagents;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;All Inhibitors;Inhibitors;Neurochemicals;Pharmaceuticals | | Mol File: | 6779-87-9.mol |  |
| | 7,8-DIHYDRO-L-BIOPTERIN Chemical Properties |
| Melting point | >300°C dec. | | Boiling point | 470.8±55.0 °C(Predicted) | | density | 1.88 | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), DMSO (Slightly) | | pka | 10.47±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Brown | | BRN | 536551 | | Stability: | Hygroscopic | | InChIKey | FEMXZDUTFRTWPE-AWFVSMACSA-N | | CAS DataBase Reference | 6779-87-9 |
| | 7,8-DIHYDRO-L-BIOPTERIN Usage And Synthesis |
| Description | BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. | | Chemical Properties | Yellow Powder | | Uses | An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G | | Uses | The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.
| | Uses | BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. | | Definition | ChEBI: L-erythro-7,8-dihydrobiopterin is a 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-7,8-dihydrobiopterin. | | references | [1] shen r, alam a, zhang y. inhibition of gtp cyclohydrolase i by pterins[j]. biochimica et biophysica acta (bba)-general subjects, 1988, 965(1): 9-15.
[2] sugiyama t, levy b d, michel t. tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells[j]. journal of biological chemistry, 2009, 284(19): 12691-12700. |
| | 7,8-DIHYDRO-L-BIOPTERIN Preparation Products And Raw materials |
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