TIMTEC-BB SBB008853;MORIN;FUSTIC;CI 75660;CI NO 75660;3,5,7,2',4'-PENTAHYDROXYFLAVONE;2',3,4',5,7-PENTAHYDROXYFLAVONE;2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on
Morin is a natural pentahydroxyflavonol with antioxidant activity. It reduces CD36 expression and oxLDL uptake in U937-derived macrophages, inhibits PIM-1 kinase in vitro (IC50 = 2.7 μM), and reduces the activity of cytochrome P450 isoform 3A4 in liver microsomes. Through these and other actions, morin has anti-oxidant, anti-inflammatory, and other actions in animal models.[Cayman Chemical]
Uses
Morin is a polyphenolic flavonoid with radical scavenging ability. In addition it maintains the potential for suppression of lipopolysaccharide-induced neuroinflammation.
Definition
ChEBI: A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.
Safety Profile
Moderately toxic by
intraperitoneal route. Mutation data
reported. When heated to decomposition it
emits acrid smoke and irritating fumes.
Purification Methods
Stir morin at room temperature with ten times its weight of absolute EtOH, then leave overnight to settle. Filter it off, and evaporate under a heat lamp to one-tenth its volume. An equal volume of water is added, and the precipitated morin is filtered off, dissolved in the minimum amount of EtOH and again precipitated with an equal volume of water. The precipitate is filtered off, washed with water and dried at 110o for 1hour (yield ca 2.5%.). [Perkins & Kalkwarf Anal Chem 28 1989 1956.] It complexes with W and Zr. [Beilstein 18 H 239, 18 III/IV 3468, 18/5 V 492.]
