ChemicalBook Product Catalog Chemical Reagents Organic reagents Acyl halide Trifluoroacetamide

Trifluoroacetamide

Trifluoroacetamide Basic information
Product Name:Trifluoroacetamide
Synonyms:Three fluoroacetaMide;TRIFLUOROACETAMIDE;TRIFLUOROACETIC ACID AMIDE;2,2,2-trifluoro-acetamid;TRIFLUOROACETAMIDE 98%;2,2,2-TRIFLOUROACETAMIDE;2,2,2-TRIFLOUROACET-AMIDE (TFAA);Trifluoroacetamide98%
CAS:354-38-1
MF:C2H2F3NO
MW:113.04
EINECS:206-559-9
Product Categories:Amides;Carbonyl Compounds;Organic Building Blocks;top;bc0001
Mol File:354-38-1.mol
Trifluoroacetamide Structure
Trifluoroacetamide Chemical Properties
Melting point 65-70 °C (lit.)
Boiling point 162.5 °C (lit.)
density 1.4176 (estimate)
Fp 162-164°C
storage temp. Store below +30°C.
solubility 460 g/L (20°C)
form Crystalline Powder or Crystals
pka12.33±0.50(Predicted)
color White to pale yellow or beige
PH3.6 (460g/l, H2O, 23℃)
Water Solubility 460 g/L (20 ºC)
BRN 1753625
InChIKeyNRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP0.725 at 23℃ and pH4.83
Dissociation constant0 at 23℃
CAS DataBase Reference354-38-1(CAS DataBase Reference)
NIST Chemistry ReferenceAcetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry SystemAcetamide, 2,2,2-trifluoro- (354-38-1)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
RIDADR 1759
WGK Germany 3
Hazard Note Harmful/Irritant
TSCA T
HazardClass 8
PackingGroup III
HS Code 29241900
MSDS Information
ProviderLanguage
2,2,2-Trifluoroacetamide English
SigmaAldrich English
ACROS English
ALFA English
Trifluoroacetamide Usage And Synthesis
Chemical Propertieswhite to pale yellow or beige crystalline powder
Uses2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.
ApplicationTrifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.
PreparationOne-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292
General DescriptionTrifluoroacetamide is a good quencher of tryptophan fluorescence.
Trifluoroacetamide Preparation Products And Raw materials
Preparation Products2-BROMO-1-(2-(TRIFLUOROMETHYL)THIAZOL-5-YL)ETHANONE-->2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBALDEHYDE-->5-(CHLOROMETHYL)-2-(TRIFLUOROMETHYL)THIAZOLE-->2-(TRIFLUOROMETHYL)PYRIMIDINE-4,6-DIOL-->TRIFLUOROACETYL ISOCYANATE,-->ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE-->(2-(TRIFLUOROMETHYL)THIAZOL-5-YL)METHANOL-->2,2-dibromoacetamide-->2,2,2-TRIFLUOROETHYLAMINE-->2,2,2-Trifluoro-N-(2,2,2-tribromo-1-hydroxyethyl)acetamide-->8-(TRIFLUOROMETHYL)-9H-PURIN-6-AMINE-->methyl 4-[(trifluoroacetyl)amino]benzoate-->TIMTEC-BB SBB000703-->Ethyl N-(trifluoroacetyl)-2-aminopropanoate
2-TRIFLUOROACETYLAMINOFLUORENE N1-[4-(4-fluorophenyl)-6-methoxypyrimidin-2-yl]-2,2,2-trifluoroacetamide N-(8-bromoH-imidazo[1,2-a]pyridin-2-yl)-2,2,2-trifluoroacetamide N-(2-IODOETHYL)TRIFLUORO-ACETAMIDE Trifluoroacetamide N-(Trifluoroacetyl)glycine 2,2,2-TRIFLUORO-N-(9-OXOFLUOREN-2-YL)ACETAMIDE (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE 2-TRIFLUOROACETAMIDO-7-NITROFLUORENE N-(6-bromoH-imidazo[1,2-a]pyridin-2-yl)-2,2,2-trifluoroacetamide (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE N,O-BIS(TRIFLUOROACETYL)HYDROXYLAMINE BOC-LYS(TFA)-OSU BISTRIFLUOROACETAMIDE N-{2-[(Z)-(dimethylamino)methylidene]-5,6-dimethoxy-3-oxo-1,3-dihydro-2H-inden-1-yl}-2,2,2-trifluoroacetamide N10-(TRIFLUOROACETYL)PTEROIC ACID N1-(2-acetyl-5-phenyl-3-thienyl)-2,2,2-trifluoroacetamide N1-[2-acetyl-5-(tert-butyl)-3-thienyl]-2,2,2-trifluoroacetamide
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