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| | Oxethazaine Basic information |
| Product Name: | Oxethazaine | | Synonyms: | OXETHAZAINE;OXETHAZINE;OXETACAINE;2-hydroxyethyliminobis(n-[α,α-dimethylphenethyl]-n-methylacetamide);2,2'-[(2-Hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methylacetamide];Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl-;C12552;2,2’-((2-hydroxyethyl)imino)bis(n-(1,1-dimethyl-2-phenylethyl)-n-methylaceta | | CAS: | 126-27-2 | | MF: | C28H41N3O3 | | MW: | 467.64 | | EINECS: | 204-780-5 | | Product Categories: | VIRAMUNE;Aromatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 126-27-2.mol |  |
| | Oxethazaine Chemical Properties |
| Melting point | 104-105°C | | Boiling point | 570.1°C (rough estimate) | | density | 1.0974 (rough estimate) | | refractive index | 1.7800 (estimate) | | storage temp. | Refrigerator | | solubility | Practically insoluble in water; freely soluble in methanol; soluble in ethyl acetate. | | form | neat | | pka | 14.62±0.10(Predicted) | | color | White to Off-White | | Water Solubility | <0.1 g/100 mL at 23 ºC | | CAS DataBase Reference | 126-27-2(CAS DataBase Reference) | | EPA Substance Registry System | Oxethazaine (126-27-2) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | AC3325000 | | Toxicity | LD50 oral in rat: 1gm/kg |
| | Oxethazaine Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Oxaine,Wyeth,US,1960 | | Uses | A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. | | Uses | antiviral, RT inhibitor | | Definition | ChEBI: Oxethazaine is an amino acid amide. | | Manufacturing Process | Chlor-N-methyl-N-ω-phenyl-tert-butyl acetamide (23.95 g) (0.1 mol) is added to n-butanol (150.0 cc) containing anhydrous potassium carbonate (50.0 g). To the stirred refluxing solution is added dropwise freshly distilled ethanolamine (3.1 g) (0.05 mol). Stirring and refluxing is maintained for twenty hours. Upon cooling the solution is filtered; the residue is washed with n-butanol. The combined filtrates are washed with aqueous sodium carbonate solution then water and finally dried over anhydrous magnesium sulfate. The solvent is distilled under vacuum leaving a dry solid residue. The residue is dissolved in dry benzene to which is added n-hexane to crystallize the product melting at 104°C to 104.5°C. Yield 71-73%. Analysis-Carbon: calc. 71.9%; found 71.93%; hydrogen: calc. 8.8%; found 8.9%; nitrogen: calc. 9.0%; found 9.0%.
To make the hydrochloride salt, the bisacetamide or, by another name, 1,11diphenyl-2,2,3,9,10,10-hexamethyl-4,8-diketo-6-(β-hydroxyethyl)-3,6,9triazaundecane is dissolved in n-butanol. The solution is chilled and then dry hydrogen chloride gas is passed into the solution causing an oil to separate. To the heavy oil ether is added and then stirred causing crystallization to occur. MP 146°C to 147°C. Analysis for nitrogen: calc. 83%. found 8.2%.
To make the acetate salt, the bisacetamide (4.7 g) (0.01 mol) is dissolved in ethyl acetate to which is added glacial acetic acid (0.6 g) (0.01 mol). Ether is added to precipitate the acetate as a gum which is washed with hexane, and finally added to dry ether. Allow to stand for crystallization. MP 141°C. Analysis for nitrogen: calc. 8.0%; found 8.2%.
Other salts are: sulfate, MP 56°C; acid oxalate, MP 127°C; tartrate, MP 45°C; picrate, MP 151°C to 152°C.
| | Therapeutic Function | Local anesthetic | | General Description | White powder. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | A hydroxylated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). | | Fire Hazard | Flash point data are not available for Oxethazaine, but Oxethazaine is probably combustible. |
| | Oxethazaine Preparation Products And Raw materials |
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