LDC1267

LDC1267 Basic information
Product Name:LDC1267
Synonyms:LDC1267;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;CS-1641;LDC 1267;LDC-1267;1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-;LDC1267 USP/EP/BP;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
CAS:1361030-48-9
MF:C30H26F2N4O5
MW:560.55
EINECS:
Product Categories:Inhibitors
Mol File:1361030-48-9.mol
LDC1267 Structure
LDC1267 Chemical Properties
Boiling point 628.4±55.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
form solid
pka9.36±0.70(Predicted)
Safety Information
MSDS Information
LDC1267 Usage And Synthesis
Biological ActivityLDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.
in vitro

LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

in vivoIn B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.
target
TargetValue
Mer
(Cell-free assay)
<5 nM
Tyro3
(Cell-free assay)
8 nM
Axl
(Cell-free assay)
29 nM
LDC1267 Preparation Products And Raw materials
Olaparib Ganetespib CAL-101 UNC2250 Lapatinib Tofacitinib citrate

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.