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| | PI-3065 Basic information |
| Product Name: | PI-3065 | | Synonyms: | PI-3065;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine;PI-3065|PI3065;4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065;PI-3065, >=98%;129556 | | CAS: | 955977-50-1 | | MF: | C27H31FN6OS | | MW: | 506.64 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 955977-50-1.mol |  |
| | PI-3065 Chemical Properties |
| density | 1.372±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | ≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | solid | | pka | 14.80±0.30(Predicted) | | CAS DataBase Reference | 955977-50-1 |
| | PI-3065 Usage And Synthesis |
| Biological Activity | pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1]. | | in vitro | PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ. | | target | | p110α 910 nM (IC 50 ) | p110β 600 nM (IC 50 ) | p110δ 5 nM (IC 50 ) | | | storage | Store at -20°C |
| | PI-3065 Preparation Products And Raw materials |
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