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| | 5-Bromo-3-nitropyridine-2-carbonitrile Basic information |
| | 5-Bromo-3-nitropyridine-2-carbonitrile Chemical Properties |
| Melting point | 101-106 °C | | Boiling point | 348.9±42.0 °C(Predicted) | | density | 1.92±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | -6.71±0.20(Predicted) | | form | powder to crystal | | color | Light orange to Yellow to Green | | InChIKey | OBVYONPVHIOJJZ-UHFFFAOYSA-N | | CAS DataBase Reference | 573675-25-9(CAS DataBase Reference) |
| Hazard Codes | T,Xi | | Risk Statements | 20/21-25-37/38-41 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Hazard Note | Toxic | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 29333990 |
| | 5-Bromo-3-nitropyridine-2-carbonitrile Usage And Synthesis |
| Chemical Properties | Yellow to light yellow crystals | | Uses | Used as an intermediate in organic synthesis. | | Synthesis |
To a stirred solution of 2,5-dibromo-3-nitro-pyridine (25 g, 88.68 mmol) in propionitrile (100 ml) was added CuCN (8.7 g, 97.55 mmol) and the mixture was heated to 90°C. for 17 h. Then it was allowed to cool to room temperature, diluted with EtOAc, washed twice with brine, dried with Na2SO4 and concentrated. The remaining residue was purified by chromatography (silica gel; DCM/MeOH 95:5- 85:15) to obtain 5-Bromo-3-nitropyridine-2-carbonitrile. Yellow solid, yield 17.5 g, 68%.
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| | 5-Bromo-3-nitropyridine-2-carbonitrile Preparation Products And Raw materials |
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