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| | (±)16-HETE Basic information |
| Product Name: | (±)16-HETE | | Synonyms: | (±)16-HETE;JEKNPVYFNMZRJG-UFINWASNSA-N;5,8,11,14-Eicosatetraenoic acid, 16-hydroxy-, (5Z,8Z,11Z,14Z)-;16-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid | | CAS: | 128914-46-5 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 128914-46-5.mol |  |
| | (±)16-HETE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
| | (±)16-HETE Usage And Synthesis |
| Description | Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity. | | Definition | ChEBI: A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 16. |
| | (±)16-HETE Preparation Products And Raw materials |
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